| http://purl.uniprot.org/citations/15474017 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15474017 | http://www.w3.org/2000/01/rdf-schema#comment | "Coactosin is a small (MW approximately 15 kDa) evolutionarily conserved actin filament binding protein. It displays remote sequence homology to ADF/cofilin proteins and to the ADF-H domains of twinfilin and Abp1/drebrin. However, biochemical analyses have demonstrated that coactosin has a very different role in actin dynamics from the ones of ADF/cofilin, twinfilin or Abp1/drebrin. To elucidate the molecular mechanism of coactosin/actin interaction, we determined the three-dimensional structure of mouse coactosin by multidimensional NMR spectroscopy. We find that the coactosin structure is homologous to ADF/cofilin and to the ADF-H domains of twinfilin. Furthermore, the regions that have been shown to be important for actin filament interactions in ADF/cofilins are structurally conserved in coactosin suggesting that these two proteins interact with F-actin through a conserved interface. Our analysis also identifies key structural differences between these proteins that may account for the differences in biochemical activities and cellular roles of these proteins."xsd:string |
| http://purl.uniprot.org/citations/15474017 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2004.08.068"xsd:string |
| http://purl.uniprot.org/citations/15474017 | http://purl.uniprot.org/core/author | "Permi P."xsd:string |
| http://purl.uniprot.org/citations/15474017 | http://purl.uniprot.org/core/author | "Lappalainen P."xsd:string |
| http://purl.uniprot.org/citations/15474017 | http://purl.uniprot.org/core/author | "Hellman M."xsd:string |
| http://purl.uniprot.org/citations/15474017 | http://purl.uniprot.org/core/author | "Annila A."xsd:string |
| http://purl.uniprot.org/citations/15474017 | http://purl.uniprot.org/core/author | "Naumanen P."xsd:string |
| http://purl.uniprot.org/citations/15474017 | http://purl.uniprot.org/core/author | "Paavilainen V.O."xsd:string |
| http://purl.uniprot.org/citations/15474017 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15474017 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/15474017 | http://purl.uniprot.org/core/pages | "91-96"xsd:string |
| http://purl.uniprot.org/citations/15474017 | http://purl.uniprot.org/core/title | "Solution structure of coactosin reveals structural homology to ADF/cofilin family proteins."xsd:string |
| http://purl.uniprot.org/citations/15474017 | http://purl.uniprot.org/core/volume | "576"xsd:string |
| http://purl.uniprot.org/citations/15474017 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15474017 |
| http://purl.uniprot.org/citations/15474017 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15474017 |
| http://purl.uniprot.org/uniprot/#_Q9CQI6-mappedCitation-15474017 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15474017 |
| http://purl.uniprot.org/uniprot/Q9CQI6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15474017 |