| http://purl.uniprot.org/citations/15483626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15483626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15483626 | http://www.w3.org/2000/01/rdf-schema#comment | "Signalling by cGMP-dependent protein kinase type I (cGKI) relaxes various smooth muscles modulating thereby vascular tone and gastrointestinal motility. cGKI-dependent relaxation is possibly mediated by phosphorylation of the inositol 1,4,5-trisphosphate receptor I (IP(3)RI)-associated protein (IRAG), which decreases hormone-induced IP(3)-dependent Ca(2+) release. We show now that the targeted deletion of exon 12 of IRAG coding for the N-terminus of the coiled-coil domain disrupted in vivo the IRAG-IP(3)RI interaction and resulted in hypomorphic IRAG(Delta12/Delta12) mice. These mice had a dilated gastrointestinal tract and a disturbed gastrointestinal motility. Carbachol- and phenylephrine-contracted smooth muscle strips from colon and aorta, respectively, of IRAG(Delta12/Delta12) mice were not relaxed by cGMP, while cAMP-mediated relaxation was unperturbed. Norepinephrine-induced increases in [Ca(2+)](i) were not decreased by cGMP in aortic smooth muscle cells from IRAG(Delta12/Delta12) mice. In contrast, cGMP-induced relaxation of potassium-induced smooth muscle contraction was not abolished in IRAG(Delta12/Delta12) mice. We conclude that cGMP-dependent relaxation of hormone receptor-triggered smooth muscle contraction essentially depends on the interaction of cGKI-IRAG with IP(3)RI."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600440"xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600440"xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Feil R."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Feil R."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Werner M."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Werner M."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Hofmann F."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Hofmann F."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Feil S."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Feil S."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Schlossmann J."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Schlossmann J."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Stieber J."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Stieber J."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Acheo L."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Acheo L."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Geiselhoeringer A."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Geiselhoeringer A."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Sigl K."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Sigl K."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Smital P."xsd:string |
| http://purl.uniprot.org/citations/15483626 | http://purl.uniprot.org/core/author | "Smital P."xsd:string |