| http://purl.uniprot.org/citations/15485634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15485634 | http://www.w3.org/2000/01/rdf-schema#comment | "TNF receptor (TNFR) superfamily members, CD40, and BAFFR play critical roles in B cell survival and differentiation. Genetic deficiency in a novel adaptor molecule, Act1, for CD40 and BAFF results in a dramatic increase in peripheral B cells, which culminates in lymphadenopathy and splenomegaly, hypergammaglobulinemia, and autoantibodies. While the B cell-specific Act1 knockout mice displayed a similar phenotype with less severity, the pathology of the Act1-deficient mice was mostly blocked in CD40-Act1 and BAFF-Act1 double knockout mice. CD40- and BAFF-mediated survival is significantly increased in Act1-deficent B cells, with stronger IkappaB phosphorylation, processing of NF-kappaB2 (p100/p52), and activation of JNK, ERK, and p38 pathways, indicating that Act1 negatively regulates CD40- and BAFF-mediated signaling events. These findings demonstrate that Act1 plays an important role in the homeostasis of B cells by attenuating CD40 and BAFFR signaling."xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2004.09.001"xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/author | "Qian Y."xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/author | "Qin J."xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/author | "Scott M."xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/author | "Ware C.F."xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/author | "Cui G."xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/author | "Naramura M."xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/author | "Omori S.A."xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/author | "Rickert R.C."xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/author | "Kotzin B.L."xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/author | "Fairchild R.L."xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/author | "Snow E.C."xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/pages | "575-587"xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/title | "Act1, a negative regulator in CD40- and BAFF-mediated B cell survival."xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/15485634 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15485634 |
| http://purl.uniprot.org/citations/15485634 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15485634 |
| http://purl.uniprot.org/uniprot/Q8N7N6#attribution-A4087ECE5B7A814573BA7DC3A2D4190E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15485634 |
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| http://purl.uniprot.org/uniprot/#_A0A0U5J6R6-mappedCitation-15485634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15485634 |