| http://purl.uniprot.org/citations/15486065 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15486065 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15486065 | http://www.w3.org/2000/01/rdf-schema#comment | "The interleukin-12 (IL-12) cytokine family plays important roles in the orchestration of innate and adaptive immunity by dendritic cells (DCs). The regulation of IL-12 expression has been thoroughly studied, but little is known about factors governing the expression of IL-23 and IL-27, 2 novel IL-12 family members acting on memory and naive T cells, respectively. We report that the expression of these cytokines by DCs was critically dependent on the mode of activation. DC activation by CD40L predominantly induced IL-12. Ligands of the Toll-like receptor (TLR) 3 and TLR4 induced IL-12 and IL-27, whereas exposure to intact Escherichia coli resulted in high expression of IL-12, IL-27, and IL-23. The nucleotide adenosine triphosphate (ATP) has been shown to inhibit IL-12 production by P2 receptors. We found that ATP also inhibited IL-27 expression but enhanced IL-23 expression. Interestingly, the reciprocal regulation of IL-12/IL-27 and IL-23 by ATP was mediated by 2 distinct P2 receptors and was also induced by prostaglandin E(2) by cyclic adenosine monophosphate (cAMP)-elevating EP2/EP4 receptors. As a consequence, DCs were selectively impaired in their ability to induce interferon-gamma (IFN-gamma) in naive T cells but continued to promote IFN-gamma and IL-17 production in memory T cells. These studies identify P2 receptors as promising targets for the design of novel strategies to manipulate specific stages of T-cell responses and to treat IL-12- and IL-23-mediated disorders."xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2004-05-1718"xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2004-05-1718"xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/author | "Wagner M."xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/author | "Wagner M."xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/author | "Shin A."xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/author | "Shin A."xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/author | "Maraskovsky E."xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/author | "Maraskovsky E."xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/author | "Toy T."xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/author | "Toy T."xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/author | "Cebon J."xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/author | "Cebon J."xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/author | "Schnurr M."xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/author | "Schnurr M."xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/pages | "1582-1589"xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/pages | "1582-1589"xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/title | "Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway."xsd:string |
| http://purl.uniprot.org/citations/15486065 | http://purl.uniprot.org/core/title | "Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway."xsd:string |