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http://purl.uniprot.org/citations/15492185http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15492185http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

To determine gene frequencies of HLA-DR alleles in 22 Mexican patients with focal epithelial hyperplasia and compare them with those present in ethnically matched healthy subjects, as well as to determine the types of human papillomavirus present in the lesions.

Design

Prospective and retrospective observational study.

Setting

Dermatology outpatient clinic in a general hospital.

Patients

Twenty-two patients with clinically and histologically confirmed focal epithelial hyperplasia seen within a 10-year period.

Interventions

None.

Main outcome measures

Results of high-resolution DNA typing for HLA-DR alleles and biopsy for viral typing.

Results

HLA-DR4 (DRB1*0404) was significantly increased (P<.001; odds ratio, 3.9; 95% confidence interval, 1.86-8.03). Seventeen (85%) of 20 patients had human papillomavirus subtype 13. The data on human papillomavirus differed from reports elsewhere that described association with human papillomavirus type 32.

Conclusions

The HLA-DRB1*0404 allele suggests that Amerindian populations are at risk, and in this group, the Mexican population studied was affected only by human papillomavirus type 13."xsd:string
http://purl.uniprot.org/citations/15492185http://purl.org/dc/terms/identifier"doi:10.1001/archderm.140.10.1227"xsd:string
http://purl.uniprot.org/citations/15492185http://purl.uniprot.org/core/author"Granados J."xsd:string
http://purl.uniprot.org/citations/15492185http://purl.uniprot.org/core/author"Ruiz-Morales J.A."xsd:string
http://purl.uniprot.org/citations/15492185http://purl.uniprot.org/core/author"Salgado N."xsd:string
http://purl.uniprot.org/citations/15492185http://purl.uniprot.org/core/author"Yamamoto-Furusho J.K."xsd:string
http://purl.uniprot.org/citations/15492185http://purl.uniprot.org/core/author"Garcia-Corona C."xsd:string
http://purl.uniprot.org/citations/15492185http://purl.uniprot.org/core/author"Mosqueda-Taylor A."xsd:string
http://purl.uniprot.org/citations/15492185http://purl.uniprot.org/core/author"Rodriguez-Carreon A.A."xsd:string
http://purl.uniprot.org/citations/15492185http://purl.uniprot.org/core/author"Vega-Memije E."xsd:string
http://purl.uniprot.org/citations/15492185http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15492185http://purl.uniprot.org/core/name"Arch Dermatol"xsd:string
http://purl.uniprot.org/citations/15492185http://purl.uniprot.org/core/pages"1227-1231"xsd:string
http://purl.uniprot.org/citations/15492185http://purl.uniprot.org/core/title"Association of HLA-DR4 (DRB1*0404) with human papillomavirus infection in patients with focal epithelial hyperplasia."xsd:string
http://purl.uniprot.org/citations/15492185http://purl.uniprot.org/core/volume"140"xsd:string
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