| http://purl.uniprot.org/citations/15492257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15492257 | http://www.w3.org/2000/01/rdf-schema#comment | "Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathways. Flot-2 protein and mRNA were increased in tumorigenic and metastatic melanoma cell lines in vitro, and the immunostaining intensity increased substantially across a tissue array of melanocytic lesions. Flot-2 transfection transformed SB2 melanoma cells from nontumorigenic, nonmetastatic to highly tumorigenic and metastatic in a nude mouse xenograft model. SB2 cells stably transfected with the flot-2 cDNA (SB2-flot)-2 cells proliferated faster in the absence of serum, and their migration through Matrigel was additionally enhanced by thrombin. When SB2-flot-2 cells were compared with SB2-vector-control cells on a cancer gene pathway array, SB2-flot-2 cells had increased expression of protease activated receptor 1 (PAR-1) mRNA, a transmembrane, G-protein-coupled receptor involved in melanoma progression. PAR-1 and flot-2 were coimmunoprecipitated from SB2-flot-2 cells. Up-regulation of PAR-1 was additionally confirmed in SB2-flot-2 cells and melanoma cell lines. SB2-flot-2 cells transfected with flot-2-specific small-interfering RNAs made substantially less flot-2 and PAR-1 mRNA. In conclusion, flot-2 overexpression is associated with melanoma progression, with increased PAR-1 expression, and with transformation of SB2 melanoma cells to a highly metastatic line. Flot-2 binds to PAR-1, a known upstream mediator of major signal transduction pathways implicated in cell growth and metastasis, and may thereby influence tumor progression."xsd:string |
| http://purl.uniprot.org/citations/15492257 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-04-0823"xsd:string |
| http://purl.uniprot.org/citations/15492257 | http://purl.uniprot.org/core/author | "George S."xsd:string |
| http://purl.uniprot.org/citations/15492257 | http://purl.uniprot.org/core/author | "Prieto V.G."xsd:string |
| http://purl.uniprot.org/citations/15492257 | http://purl.uniprot.org/core/author | "Bar-Eli M."xsd:string |
| http://purl.uniprot.org/citations/15492257 | http://purl.uniprot.org/core/author | "Duvic M."xsd:string |
| http://purl.uniprot.org/citations/15492257 | http://purl.uniprot.org/core/author | "Koul D."xsd:string |
| http://purl.uniprot.org/citations/15492257 | http://purl.uniprot.org/core/author | "Babu D."xsd:string |
| http://purl.uniprot.org/citations/15492257 | http://purl.uniprot.org/core/author | "McCarty M.F."xsd:string |
| http://purl.uniprot.org/citations/15492257 | http://purl.uniprot.org/core/author | "Hazarika P."xsd:string |
| http://purl.uniprot.org/citations/15492257 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15492257 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/15492257 | http://purl.uniprot.org/core/pages | "7361-7369"xsd:string |
| http://purl.uniprot.org/citations/15492257 | http://purl.uniprot.org/core/title | "Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1."xsd:string |
| http://purl.uniprot.org/citations/15492257 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/15492257 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15492257 |
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