| http://purl.uniprot.org/citations/15492845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15492845 | http://www.w3.org/2000/01/rdf-schema#comment | "The Notch-1 and Notch-2 receptors play crucial roles in cell fate determination through interaction with the Delta/Serrate/Lag-2 family of ligands. The function of Notch signalling in tumourigenesis is still unclear, however, reports have demonstrated unregulated Notch activity in a variety of human cancers. We quantified Notch-1 and Notch-2 expression, in association with clinical outcome, in tissue samples from breast cancer patients (normal specimens n=24, breast cancer specimens n=97). We used qualitative and quantitative RT-PCR analysis, along with immunohistochemical staining to examine Notch-1 and Notch-2 expression in association with the patients clinical parameters (median follow-up 72 months). Our results show that there are aberrant levels of Notch-1 and Notch-2 in breast cancer tissues compared with normal breast tissue. Examination of the breast cancer patients' clinicopathological parameters reported that a high level of Notch-1 may be associated with a poorer outlook for the breast cancer patient, while a high level of Notch-2 correlated to a higher chance of survival. Notch-1 and Notch-2 also appear to play crucial and contrasting roles in breast tumour differentiation. Notch-1 expression was low in grade 1 tumours and increased in poorly-differentiated tumours, whereas, Notch-2 expression was high in well-differentiated tumours and reduced in breast tumours with poor differentiation. Therefore, Notch-1 may possess tumour-promoting functions, while Notch-2 could play a tumour-suppressive role in human breast cancer. These results support the notion that suppression of Notch-1 activity may represent a novel therapeutic strategy."xsd:string |
| http://purl.uniprot.org/citations/15492845 | http://purl.org/dc/terms/identifier | "doi:10.3892/ijmm.14.5.779"xsd:string |
| http://purl.uniprot.org/citations/15492845 | http://purl.uniprot.org/core/author | "Jiang W.G."xsd:string |
| http://purl.uniprot.org/citations/15492845 | http://purl.uniprot.org/core/author | "Parr C."xsd:string |
| http://purl.uniprot.org/citations/15492845 | http://purl.uniprot.org/core/author | "Watkins G."xsd:string |
| http://purl.uniprot.org/citations/15492845 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15492845 | http://purl.uniprot.org/core/name | "Int J Mol Med"xsd:string |
| http://purl.uniprot.org/citations/15492845 | http://purl.uniprot.org/core/pages | "779-786"xsd:string |
| http://purl.uniprot.org/citations/15492845 | http://purl.uniprot.org/core/title | "The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer."xsd:string |
| http://purl.uniprot.org/citations/15492845 | http://purl.uniprot.org/core/volume | "14"xsd:string |
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