| http://purl.uniprot.org/citations/15494308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15494308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15494308 | http://www.w3.org/2000/01/rdf-schema#comment | "T4 RNA ligase 2 (Rnl2) exemplifies a family of RNA-joining enzymes that includes protozoan RNA-editing ligases. Rnl2 efficiently seals 3'-OH/5'-PO4 RNA nicks in either a duplex RNA or an RNA:DNA hybrid but cannot seal DNA nicks. RNA specificity arises from a requirement for at least two ribonucleotides immediately flanking the 3'-OH of the nick; the rest of the nicked duplex can be replaced by DNA. The terminal 2'-OH at the nick is important for the attack of the 3'-OH on the 5'-adenylated strand to form a phosphodiester, but dispensable for nick recognition and adenylylation of the 5'-PO4 strand. The penultimate 2'-OH is important for nick recognition. Stable binding of Rnl2 at a nick depends on contacts to both the N-terminal adenylyltransferase domain and its signature C-terminal domain. Nick sensing also requires adenylylation of Rnl2. These results provide insights to the evolution of nucleic acid repair systems."xsd:string |
| http://purl.uniprot.org/citations/15494308 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2004.09.022"xsd:string |
| http://purl.uniprot.org/citations/15494308 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2004.09.022"xsd:string |
| http://purl.uniprot.org/citations/15494308 | http://purl.uniprot.org/core/author | "Shuman S."xsd:string |
| http://purl.uniprot.org/citations/15494308 | http://purl.uniprot.org/core/author | "Shuman S."xsd:string |
| http://purl.uniprot.org/citations/15494308 | http://purl.uniprot.org/core/author | "Nandakumar J."xsd:string |
| http://purl.uniprot.org/citations/15494308 | http://purl.uniprot.org/core/author | "Nandakumar J."xsd:string |
| http://purl.uniprot.org/citations/15494308 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15494308 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15494308 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15494308 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15494308 | http://purl.uniprot.org/core/pages | "211-221"xsd:string |
| http://purl.uniprot.org/citations/15494308 | http://purl.uniprot.org/core/pages | "211-221"xsd:string |
| http://purl.uniprot.org/citations/15494308 | http://purl.uniprot.org/core/title | "How an RNA ligase discriminates RNA versus DNA damage."xsd:string |
| http://purl.uniprot.org/citations/15494308 | http://purl.uniprot.org/core/title | "How an RNA ligase discriminates RNA versus DNA damage."xsd:string |
| http://purl.uniprot.org/citations/15494308 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/15494308 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/15494308 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15494308 |
| http://purl.uniprot.org/citations/15494308 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15494308 |
| http://purl.uniprot.org/citations/15494308 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15494308 |
| http://purl.uniprot.org/citations/15494308 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15494308 |
| http://purl.uniprot.org/uniprot/P32277 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15494308 |
| http://purl.uniprot.org/uniprot/P32277#attribution-6F25635CC2DC6DD12373421F96DE0995 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15494308 |