| http://purl.uniprot.org/citations/15494511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15494511 | http://www.w3.org/2000/01/rdf-schema#comment | "Human HLA-B*3501 binds an antigenic peptide of 14-aa length derived from an alternative reading frame of M-CSF with high affinity. Due to its extraordinary length, the exact HLA binding mode was unpredictable. The crystal structure of HLA-B*3501 at 1.5 A shows that the N and C termini of the peptide are embedded in the A and F pockets, respectively, similar to a peptide of normal length. The central part of the 14-meric peptide bulges flexibly out of the groove. Two variants of the alternative reading frame of M-CSF peptide substituted at P2 or P2 and P9 with Ala display weak or no T cell activation. Their structure differs mainly in flexibility and conformation from the agonistic peptide. Moreover, the variants induce subtle changes of MHC alpha-helical regions implicated as critical for TCR contact. The TCR specifically recognizing this peptide/MHC complex exhibits CDR3 length within the normal range, suggesting major conformational adaptations of this receptor upon peptide/MHC binding. Thus, the potential antigenic repertoire recognizable by CTLs is larger than currently thought."xsd:string |
| http://purl.uniprot.org/citations/15494511 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.173.9.5610"xsd:string |
| http://purl.uniprot.org/citations/15494511 | http://purl.uniprot.org/core/author | "Herrmann H."xsd:string |
| http://purl.uniprot.org/citations/15494511 | http://purl.uniprot.org/core/author | "Weiss S."xsd:string |
| http://purl.uniprot.org/citations/15494511 | http://purl.uniprot.org/core/author | "Hecht H.J."xsd:string |
| http://purl.uniprot.org/citations/15494511 | http://purl.uniprot.org/core/author | "Probst-Kepper M."xsd:string |
| http://purl.uniprot.org/citations/15494511 | http://purl.uniprot.org/core/author | "Janke V."xsd:string |
| http://purl.uniprot.org/citations/15494511 | http://purl.uniprot.org/core/author | "Klempnauer J."xsd:string |
| http://purl.uniprot.org/citations/15494511 | http://purl.uniprot.org/core/author | "Ocklenburg F."xsd:string |
| http://purl.uniprot.org/citations/15494511 | http://purl.uniprot.org/core/author | "van den Eynde B.J."xsd:string |
| http://purl.uniprot.org/citations/15494511 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15494511 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15494511 | http://purl.uniprot.org/core/pages | "5610-5616"xsd:string |
| http://purl.uniprot.org/citations/15494511 | http://purl.uniprot.org/core/title | "Conformational restraints and flexibility of 14-meric peptides in complex with HLA-B*3501."xsd:string |
| http://purl.uniprot.org/citations/15494511 | http://purl.uniprot.org/core/volume | "173"xsd:string |
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