| http://purl.uniprot.org/citations/15496200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15496200 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies of sporadic inclusion body myositis (sIBM) have shown a strong association with HLA-DR3 and other components of the 8.1 ancestral haplotype (AH) (HLA-A1, B8, DR3), where the susceptibility locus has been mapped to the central major histocompatibility complex (MHC) region between HLA-DR and C4. Here, the association with HLA-DR3 and other genes in the central MHC and class II region was further investigated in a group of 42 sIBM patients and in an ethnically similar control group (n = 214), using single-nucleotide polymorphisms and microsatellite screening. HLA-DR3 (marking DRB1*0301 in Caucasians) was associated with sIBM (Fisher's test). However, among HLA-DR3-positive patients and controls, carriage of HLA-DR3 without microsatellite and single-nucleotide polymorphism alleles of the 8.1AH (HLA-A1, B8, DRB3*0101, DRB1*0301, DQB1*0201) was marginally less common in patients. Patients showed no increase in carriage of the 18.2AH (HLA-A30, B18, DRB3*0202, DRB1*0301, DQB1*0201) or HLA-DR3 without the central MHC of the 8.1AH, further arguing against HLA-DRB1 as the direct cause of susceptibility. Genes between HLA-DRB1 and HOX12 require further investigation. BTL-II lies in this region and is expressed in muscle. Carriage of allele 2 (exon 6) was more common in patients. BTL-II(E6)*2 is characteristic of the 35.2AH (HLA-A3, B35, DRB1*01) in Caucasians and HLA-DR1, BTL-II(E6)*2, HOX12*2, RAGE*2 was carried by several patients. The 8.1AH and 35.2AH may confer susceptibility to sIBM independently or share a critical allele."xsd:string |
| http://purl.uniprot.org/citations/15496200 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1399-0039.2004.00310.x"xsd:string |
| http://purl.uniprot.org/citations/15496200 | http://purl.uniprot.org/core/author | "Laing N."xsd:string |
| http://purl.uniprot.org/citations/15496200 | http://purl.uniprot.org/core/author | "Kok C.C."xsd:string |
| http://purl.uniprot.org/citations/15496200 | http://purl.uniprot.org/core/author | "Allcock R."xsd:string |
| http://purl.uniprot.org/citations/15496200 | http://purl.uniprot.org/core/author | "Price P."xsd:string |
| http://purl.uniprot.org/citations/15496200 | http://purl.uniprot.org/core/author | "Mastaglia F."xsd:string |
| http://purl.uniprot.org/citations/15496200 | http://purl.uniprot.org/core/author | "Garlepp M."xsd:string |
| http://purl.uniprot.org/citations/15496200 | http://purl.uniprot.org/core/author | "Santoso L."xsd:string |
| http://purl.uniprot.org/citations/15496200 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15496200 | http://purl.uniprot.org/core/name | "Tissue Antigens"xsd:string |
| http://purl.uniprot.org/citations/15496200 | http://purl.uniprot.org/core/pages | "575-580"xsd:string |
| http://purl.uniprot.org/citations/15496200 | http://purl.uniprot.org/core/title | "Two major histocompatibility complex haplotypes influence susceptibility to sporadic inclusion body myositis: critical evaluation of an association with HLA-DR3."xsd:string |
| http://purl.uniprot.org/citations/15496200 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/15496200 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15496200 |
| http://purl.uniprot.org/citations/15496200 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15496200 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-15496200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15496200 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-15496200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15496200 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-15496200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15496200 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-15496200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15496200 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-15496200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15496200 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-15496200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15496200 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-15496200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15496200 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-15496200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15496200 |