| http://purl.uniprot.org/citations/15496610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15496610 | http://www.w3.org/2000/01/rdf-schema#comment | "Tracheal aspirate IL-8 concentration and airway epithelial cell IL-8 expression are each increased in premature infants undergoing mechanical ventilation. We sought to determine the cytokines responsible for IL-8 expression in this context. Tracheal aspirates were collected from 18 mechanically ventilated premature infants. IL-8 protein abundance was high in tracheal aspirates from ventilated premature infants (mean, 5806 +/-4923 pg/mL). IL-1 alpha (mean, 20 +/- 6 pg/mL), IL-1 beta (mean 67 +/-46 pg/mL), and tumor necrosis factor (TNF)-alpha (mean, 8 +/-2 pg/mL) were also found. Incubation of tracheal aspirates with 16HBE14o-human bronchial epithelial cells increased IL-8 protein in both cell lysates and supernatants, as well as transcription from the IL-8 promoter. Aspirates also induced nuclear factor (NF)-kappa B activation. Mutation of the IL-8 promoter NF-kappa B site abolished aspirate-induced IL-8 transcription. Endotoxin concentrations in the tracheal aspirates were negligible and incapable of inducing IL-8 promoter activity. Finally, incubation of tracheal aspirates with a neutralizing antibody against IL-1 beta reduced epithelial cell IL-8 production, whereas neutralizing antibodies against IL-1 alpha and TNF-alpha had no effect. We conclude that airway fluid from mechanically ventilated premature infants contains soluble factors capable of inducing airway epithelial cell IL-8 expression via a NF-kappa B-dependent pathway, and that IL-1 beta plays a specific role in this process."xsd:string |
| http://purl.uniprot.org/citations/15496610 | http://purl.org/dc/terms/identifier | "doi:10.1203/01.pdr.0000145274.47221.10"xsd:string |
| http://purl.uniprot.org/citations/15496610 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/15496610 | http://purl.uniprot.org/core/author | "Tan A."xsd:string |
| http://purl.uniprot.org/citations/15496610 | http://purl.uniprot.org/core/author | "Page K."xsd:string |
| http://purl.uniprot.org/citations/15496610 | http://purl.uniprot.org/core/author | "Brasier A.R."xsd:string |
| http://purl.uniprot.org/citations/15496610 | http://purl.uniprot.org/core/author | "Hershenson M.B."xsd:string |
| http://purl.uniprot.org/citations/15496610 | http://purl.uniprot.org/core/author | "Izhar F.M."xsd:string |
| http://purl.uniprot.org/citations/15496610 | http://purl.uniprot.org/core/author | "Rumilla K."xsd:string |
| http://purl.uniprot.org/citations/15496610 | http://purl.uniprot.org/core/author | "Schreiber M.D."xsd:string |
| http://purl.uniprot.org/citations/15496610 | http://purl.uniprot.org/core/author | "Shimotake T.K."xsd:string |
| http://purl.uniprot.org/citations/15496610 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15496610 | http://purl.uniprot.org/core/name | "Pediatr Res"xsd:string |
| http://purl.uniprot.org/citations/15496610 | http://purl.uniprot.org/core/pages | "907-913"xsd:string |
| http://purl.uniprot.org/citations/15496610 | http://purl.uniprot.org/core/title | "Interleukin (IL)-1 beta in tracheal aspirates from premature infants induces airway epithelial cell IL-8 expression via an NF-kappa B dependent pathway."xsd:string |
| http://purl.uniprot.org/citations/15496610 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/15496610 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15496610 |
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| http://purl.uniprot.org/uniprot/#_B5BUQ8-mappedCitation-15496610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15496610 |
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