| http://purl.uniprot.org/citations/15496924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15496924 | http://www.w3.org/2000/01/rdf-schema#comment | "The functional importance of the roughly 98% of mammalian genomes not corresponding to protein coding sequences remains largely undetermined. Here we show that some large-scale deletions of the non-coding DNA referred to as gene deserts can be well tolerated by an organism. We deleted two large non-coding intervals, 1,511 kilobases and 845 kilobases in length, from the mouse genome. Viable mice homozygous for the deletions were generated and were indistinguishable from wild-type littermates with regard to morphology, reproductive fitness, growth, longevity and a variety of parameters assaying general homeostasis. Further detailed analysis of the expression of multiple genes bracketing the deletions revealed only minor expression differences in homozygous deletion and wild-type mice. Together, the two deleted segments harbour 1,243 non-coding sequences conserved between humans and rodents (more than 100 base pairs, 70% identity). Some of the deleted sequences might encode for functions unidentified in our screen; nonetheless, these studies further support the existence of potentially 'disposable DNA' in the genomes of mammals."xsd:string |
| http://purl.uniprot.org/citations/15496924 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature03022"xsd:string |
| http://purl.uniprot.org/citations/15496924 | http://purl.uniprot.org/core/author | "Rubin E.M."xsd:string |
| http://purl.uniprot.org/citations/15496924 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/15496924 | http://purl.uniprot.org/core/author | "Nobrega M.A."xsd:string |
| http://purl.uniprot.org/citations/15496924 | http://purl.uniprot.org/core/author | "Afzal V."xsd:string |
| http://purl.uniprot.org/citations/15496924 | http://purl.uniprot.org/core/author | "Plajzer-Frick I."xsd:string |
| http://purl.uniprot.org/citations/15496924 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15496924 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/15496924 | http://purl.uniprot.org/core/pages | "988-993"xsd:string |
| http://purl.uniprot.org/citations/15496924 | http://purl.uniprot.org/core/title | "Megabase deletions of gene deserts result in viable mice."xsd:string |
| http://purl.uniprot.org/citations/15496924 | http://purl.uniprot.org/core/volume | "431"xsd:string |
| http://purl.uniprot.org/citations/15496924 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15496924 |
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