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http://purl.uniprot.org/citations/15506291http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15506291http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To explore curative machanism of Shenle capsule on the 5/6 nephrectomy rats.

Method

Fibrin plate method was applied to examine activity of urinary plasminogen activator(PA). Semi-quantitative analysis was used to observe stained intensity and area of tissue-type plasminogen activator, urokinas-type plasminogen activator/ plasminogen activator inhibitor(tPA, uPA/PAI-1)in remnant renal tissue. Northern blot was employed to analyze the expression of transforming growth factor (TGF-beta) mRNA.

Result

In model control group, the urinary PA activity and protein expression of tPA, uPA were down-regulated, but protein expression of PAI-1, TGF-beta mRNA was up-regulated in remnant renal tissue. In each treated group, the urinary PA activity and protein expression of tPA/uPA were enhanced,but the protein expression of PAI-1, TGF-beta mRNA decreased simultaneously.

Conclusion

Shenle capsule can delay glomerulosclersis and tubulointerstitial fibrotic lesions of remnant kidney by improving the activity of urinary PA and modulating the expression of tPA, uPA/PAI-1 and TGF-beta mRNA."xsd:string
http://purl.uniprot.org/citations/15506291http://purl.uniprot.org/core/author"Zhang W.X."xsd:string
http://purl.uniprot.org/citations/15506291http://purl.uniprot.org/core/author"Chen X.M."xsd:string
http://purl.uniprot.org/citations/15506291http://purl.uniprot.org/core/author"Wei R.B."xsd:string
http://purl.uniprot.org/citations/15506291http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15506291http://purl.uniprot.org/core/name"Zhongguo Zhong Yao Za Zhi"xsd:string
http://purl.uniprot.org/citations/15506291http://purl.uniprot.org/core/pages"770-773"xsd:string
http://purl.uniprot.org/citations/15506291http://purl.uniprot.org/core/title"[Curative machanism of Shenle capsule on 5/6 nephrectomy rats]."xsd:string
http://purl.uniprot.org/citations/15506291http://purl.uniprot.org/core/volume"29"xsd:string
http://purl.uniprot.org/citations/15506291http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15506291
http://purl.uniprot.org/citations/15506291http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15506291
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http://purl.uniprot.org/uniprot/#_P29598-mappedCitation-15506291http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15506291
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http://purl.uniprot.org/uniprot/P29598http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/15506291