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http://purl.uniprot.org/citations/15506939 | http://www.w3.org/2000/01/rdf-schema#comment | "The low-affinity receptor for IgG, FcgammaRIIB, negatively regulates BCR (B-cell antigen receptor)-mediated proliferative signalling and thus plays an important role in feedback inhibition of the humoral immune response. Whereas crosslinking of BCR on mature B-cells results in proliferation, co-ligation of FcgammaRIIB results in growth arrest and apoptosis. We have now investigated the signals underlying FcgammaRIIB-driven apoptosis and found this to be dependent on disruption of mitochondrial potential (Deltapsi), involve the pro-apoptotic Bcl-2 family members, Bid and Bad, and be caspase-independent."xsd:string |
http://purl.uniprot.org/citations/15506939 | http://purl.org/dc/terms/identifier | "doi:10.1042/bst0320973"xsd:string |
http://purl.uniprot.org/citations/15506939 | http://purl.uniprot.org/core/author | "Harnett M.M."xsd:string |
http://purl.uniprot.org/citations/15506939 | http://purl.uniprot.org/core/author | "Carter N.A."xsd:string |
http://purl.uniprot.org/citations/15506939 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
http://purl.uniprot.org/citations/15506939 | http://purl.uniprot.org/core/name | "Biochem Soc Trans"xsd:string |
http://purl.uniprot.org/citations/15506939 | http://purl.uniprot.org/core/pages | "973-975"xsd:string |
http://purl.uniprot.org/citations/15506939 | http://purl.uniprot.org/core/title | "Dissection of the signalling mechanisms underlying FcgammaRIIB-mediated apoptosis of mature B-cells."xsd:string |
http://purl.uniprot.org/citations/15506939 | http://purl.uniprot.org/core/volume | "32"xsd:string |
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