| http://purl.uniprot.org/citations/15507209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15507209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15507209 | http://www.w3.org/2000/01/rdf-schema#comment | "A single transcript in its unspliced and spliced forms directs the synthesis of all HIV-1 proteins. Although nuclear export of intron-containing cellular transcripts is restricted in mammalian cells, HIV-1 has evolved the viral Rev protein to overcome this restriction for viral transcripts. Previously, CRM1 was identified as a cellular cofactor for Rev-dependent export of intron-containing HIV-1 RNA. Here, we present evidence that Rev/CRM1 activity utilizes the ATP-dependent DEAD box RNA helicase, DDX3. We show that DDX3 is a nucleo-cytoplasmic shuttling protein, which binds CRM1 and localizes to nuclear membrane pores. Knockdown of DDX3 using either antisense vector or dominant-negative mutants suppressed Rev-RRE-function in the export of incompletely spliced HIV-1 RNAs. Plausibly, DDX3 is the human RNA helicase which functions in the CRM1 RNA export pathway analogously to the postulated role for Dbp5p in yeast mRNA export."xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.09.029"xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.09.029"xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/author | "Jeang K.-T."xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/author | "Jeang K.-T."xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/author | "Kleiman L."xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/author | "Kleiman L."xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/author | "Chi Y.-H."xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/author | "Chi Y.-H."xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/author | "Neuveut C."xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/author | "Neuveut C."xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/author | "Yedavalli V.S."xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/author | "Yedavalli V.S."xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/pages | "381-392"xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/pages | "381-392"xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/title | "Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function."xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/title | "Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function."xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/15507209 | http://purl.uniprot.org/core/volume | "119"xsd:string |