| http://purl.uniprot.org/citations/15507212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15507212 | http://www.w3.org/2000/01/rdf-schema#comment | "Motile and morphogenetic cellular processes are driven by site-directed assembly of actin filaments. Formins, proteins characterized by formin homology domains FH1 and FH2, are initiators of actin assembly. How formins simply bind to filament barbed ends in rapid equilibrium or find free energy to become a processive motor of filament assembly remains enigmatic. Here we demonstrate that the FH1-FH2 domain accelerates hydrolysis of ATP coupled to profilin-actin polymerization and uses the derived free energy for processive polymerization, increasing 15-fold the rate constant for profilin-actin association to barbed ends. Profilin is required for and takes part in the processive function. Single filaments grow at least 10 microm long from formin bound beads without detaching. Transitory formin-associated processes are generated by poisoning of the processive cycle by barbed-end capping proteins. We successfully reconstitute formin-induced motility in vitro, demonstrating that this mechanism accounts for the puzzlingly rapid formin-induced actin processes observed in vivo."xsd:string |
| http://purl.uniprot.org/citations/15507212 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.09.039"xsd:string |
| http://purl.uniprot.org/citations/15507212 | http://purl.uniprot.org/core/author | "Carlier M.F."xsd:string |
| http://purl.uniprot.org/citations/15507212 | http://purl.uniprot.org/core/author | "Didry D."xsd:string |
| http://purl.uniprot.org/citations/15507212 | http://purl.uniprot.org/core/author | "Egile C."xsd:string |
| http://purl.uniprot.org/citations/15507212 | http://purl.uniprot.org/core/author | "Romero S."xsd:string |
| http://purl.uniprot.org/citations/15507212 | http://purl.uniprot.org/core/author | "Pantaloni D."xsd:string |
| http://purl.uniprot.org/citations/15507212 | http://purl.uniprot.org/core/author | "Le Clainche C."xsd:string |
| http://purl.uniprot.org/citations/15507212 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15507212 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/15507212 | http://purl.uniprot.org/core/pages | "419-429"xsd:string |
| http://purl.uniprot.org/citations/15507212 | http://purl.uniprot.org/core/title | "Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis."xsd:string |
| http://purl.uniprot.org/citations/15507212 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/15507212 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15507212 |
| http://purl.uniprot.org/citations/15507212 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15507212 |
| http://purl.uniprot.org/uniprot/#_O95466-mappedCitation-15507212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15507212 |
| http://purl.uniprot.org/uniprot/#_P07737-mappedCitation-15507212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15507212 |
| http://purl.uniprot.org/uniprot/#_P08134-mappedCitation-15507212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15507212 |
| http://purl.uniprot.org/uniprot/#_P35080-mappedCitation-15507212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15507212 |
| http://purl.uniprot.org/uniprot/#_P60709-mappedCitation-15507212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15507212 |
| http://purl.uniprot.org/uniprot/#_P60953-mappedCitation-15507212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15507212 |
| http://purl.uniprot.org/uniprot/#_P63000-mappedCitation-15507212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15507212 |
| http://purl.uniprot.org/uniprot/#_P63261-mappedCitation-15507212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15507212 |
| http://purl.uniprot.org/uniprot/#_Q8IVF7-mappedCitation-15507212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15507212 |