| http://purl.uniprot.org/citations/15507443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15507443 | http://www.w3.org/2000/01/rdf-schema#comment | "The function of cyclophilin C-associated protein (CyC-AP) on expression of extracellular matrix and matrix metalloproteinases (MMPs) was studied in CyC-AP-null mice. Fibronectin showed increased expression of the 53- and 29-kDa fragments in skin and wounds from CyC-AP-null mice. Type I collagen had an initial degraded pattern in the skin of CyC-AP-null mice, which did not occur in wild-type mice. MMP-3, MMP-13, MMP-14, and tumor necrosis factor-alpha (TNFalpha) had a higher expression in CyC-AP-null skin. During wound healing, MMP-13 and TNFalpha were stimulated to an even higher level, suggesting they are regulated by multiple factors. To understand the regulatory mechanisms of the up-regulated MMPs, the direct effects of TNFalpha, IL-1beta, 45-kDa fibronectin fragment (FN-45), and the 70-kDa fibronectin fragments (FN-70) on the expression of MMPs were studied. MMP-13 expression increased significantly in both CyC-AP-null and wild-type dermal fibroblasts after treatment with IL-1beta or with TNFalpha. However, MMP-13 expression did not increase in CyC-AP-null fibroblasts but did increase only in wild-type fibroblasts after FN-45 and FN-70 treatment. MMP-3 activation was induced by FN-45 and did not show a difference between CyC-AP-null and wild-type fibroblasts, suggesting different regulatory pathways for FN-45 on MMP-13 and MMP-3 expression. Our data are the first to demonstrate that deletion of CyC-AP can abolish fibronectin fragment-induced MMP-13 expression through an unknown mechanism. CyC-AP is an important factor for the regulation of MMP-13 expression."xsd:string |
| http://purl.uniprot.org/citations/15507443 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m410804200"xsd:string |
| http://purl.uniprot.org/citations/15507443 | http://purl.uniprot.org/core/author | "Kong W."xsd:string |
| http://purl.uniprot.org/citations/15507443 | http://purl.uniprot.org/core/author | "Longaker M.T."xsd:string |
| http://purl.uniprot.org/citations/15507443 | http://purl.uniprot.org/core/author | "Lorenz H.P."xsd:string |
| http://purl.uniprot.org/citations/15507443 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15507443 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15507443 | http://purl.uniprot.org/core/pages | "55334-55340"xsd:string |
| http://purl.uniprot.org/citations/15507443 | http://purl.uniprot.org/core/title | "Cyclophilin C-associated protein is a mediator for fibronectin fragment-induced matrix metalloproteinase-13 expression."xsd:string |
| http://purl.uniprot.org/citations/15507443 | http://purl.uniprot.org/core/volume | "279"xsd:string |
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