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http://purl.uniprot.org/citations/15507967http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15507967http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The purpose of this study was to determine the relationship between preterm premature rupture of membranes, tumor necrosis factor-alpha, and heat shock protein-70 gene polymorphisms in multifetal gestations.

Study design

Buccal swabs from 101 mother-neonate pairs of multifetal pregnancies were tested for single nucleotide polymorphisms at position -308 of the tumor necrosis factor-alpha gene and +1267 of the heat shock protein-70 gene. Pregnancy outcome data were obtained subsequently.

Results

Tumor necrosis factor-alpha allele 2 carriage by the first-born occurred in 10 of 27 pregnancies (37.0%) that resulted in preterm premature rupture of membranes compared with 6 of 67 pregnancies (9.0%) without preterm premature rupture of membranes ( P = .002). The allele frequency of tumor necrosis factor-alpha allele 2 and heat shock protein-70 allele 2 in the first born was higher in pregnancies that were complicated by preterm premature rupture of membranes (18.5% vs 4.5%; P = .003; and 57.7% vs 41.3%; P = .04, respectively). There was no relationship between tumor necrosis factor-alpha allele 2 or heat shock protein-70 allele 2 carriage by the second fetus or mother and preterm premature rupture of membranes.

Conclusion

Tumor necrosis factor-alpha allele 2 and/or heat shock protein-70 allele 2 carriage by the first-born fetus is associated with preterm premature rupture of membranes in multifetal pregnancies."xsd:string
http://purl.uniprot.org/citations/15507967http://purl.org/dc/terms/identifier"doi:10.1016/j.ajog.2004.07.007"xsd:string
http://purl.uniprot.org/citations/15507967http://purl.uniprot.org/core/author"Gupta M."xsd:string
http://purl.uniprot.org/citations/15507967http://purl.uniprot.org/core/author"Vardhana S."xsd:string
http://purl.uniprot.org/citations/15507967http://purl.uniprot.org/core/author"Witkin S.S."xsd:string
http://purl.uniprot.org/citations/15507967http://purl.uniprot.org/core/author"Chasen S.T."xsd:string
http://purl.uniprot.org/citations/15507967http://purl.uniprot.org/core/author"Kalish R.B."xsd:string
http://purl.uniprot.org/citations/15507967http://purl.uniprot.org/core/author"Perni S.C."xsd:string
http://purl.uniprot.org/citations/15507967http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15507967http://purl.uniprot.org/core/name"Am J Obstet Gynecol"xsd:string
http://purl.uniprot.org/citations/15507967http://purl.uniprot.org/core/pages"1368-1374"xsd:string
http://purl.uniprot.org/citations/15507967http://purl.uniprot.org/core/title"Polymorphisms in the tumor necrosis factor-alpha gene at position -308 and the inducible 70 kd heat shock protein gene at position +1267 in multifetal pregnancies and preterm premature rupture of fetal membranes."xsd:string
http://purl.uniprot.org/citations/15507967http://purl.uniprot.org/core/volume"191"xsd:string
http://purl.uniprot.org/citations/15507967http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15507967
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