| http://purl.uniprot.org/citations/15513966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15513966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15513966 | http://www.w3.org/2000/01/rdf-schema#comment | "MUC1 (CD227) is a large transmembrane epithelial mucin glycoprotein, which is aberrantly overexpressed in most adenocarcinomas and is a target for immune therapy for epithelial tumors. Recently, MUC1 has been detected in a variety of hematopoietic cell malignancies including T and B cell lymphomas and myelomas; however, its function in these cells is not clearly defined. Using the Jurkat T cell lymphoma cell line and normal human T cells, we demonstrate that MUC1 is not only expressed in these cells but is also phosphorylated upon T cell receptor (TCR) ligation and associates with the Src-related T cell tyrosine kinase, p56lck. Upon TCR-mediated activation of Jurkat cells, MUC1 is found in the low-density membrane fractions, where linker of T cell activation is contained. Abrogation of MUC1 expression in Jurkat cells by MUC1-specific small interfering RNA resulted in defects in TCR-mediated downstream signaling events associated with T cell activation. These include reduction in Ca2+ influx and extracellular signal-regulated kinase 1/2 phosphorylation, leading to a decrease in CD69 expression, proliferation, and interleukin-2 production. These results suggest a regulatory role of MUC1 in modulating proximal signal transduction events through its interaction with proteins of the activation complex."xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0604333"xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0604333"xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/author | "Mukherjee P."xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/author | "Mukherjee P."xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/author | "Gendler S.J."xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/author | "Gendler S.J."xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/author | "Basu G.D."xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/author | "Basu G.D."xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/author | "Tinder T.L."xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/author | "Tinder T.L."xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/name | "J. Leukoc. Biol."xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/name | "J. Leukoc. Biol."xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/pages | "90-99"xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/pages | "90-99"xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/title | "MUC1 (CD227) interacts with lck tyrosine kinase in Jurkat lymphoma cells and normal T cells."xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/title | "MUC1 (CD227) interacts with lck tyrosine kinase in Jurkat lymphoma cells and normal T cells."xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/15513966 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15513966 |
| http://purl.uniprot.org/citations/15513966 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15513966 |