| http://purl.uniprot.org/citations/15516339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15516339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15516339 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphorylation of nuclear factor-kappa B (NF-kappa B) subunits emerges as a mechanism by which transcriptional activity of nuclear NF-kappa B complexes is regulated in an inhibitor kappa B-independent fashion. As the main transactivator, the p65 subunit of NF-kappa B has an outstanding position in the hierarchy of NF-kappa B proteins. p65 is a multiply phosphorylated protein with phosphorylation sites in the C-terminal transactivation domain and the N-terminal Rel homology domain (RHD). In this study, we describe two previously non-reported phospho-acceptor sites within the p65 RHD. We show that differential phosphorylation of serine residues within the RHD modulates transcriptional activity in a cis-acting element and promoter-specific context, thus leading to a phosphorylation state-dependent gene expression profile. RelA(-/-) mouse embryonic fibroblasts reconstituted with wild-type p65 or p65 phosphorylation-deficient mutants showed a distinctive expression profile of synthetic kappa B-dependent reporters as well as endogenous genes. Hypophosphorylated p65 did not display cis-acting element-specific changes in DNA binding or dimerization behavior. This study shows for the first time that site-specific phosphorylation can target a transcription factor to a particular subset of genes."xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m409344200"xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m409344200"xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/author | "Anrather J."xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/author | "Anrather J."xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/author | "Iadecola C."xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/author | "Iadecola C."xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/author | "Racchumi G."xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/author | "Racchumi G."xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/pages | "244-252"xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/pages | "244-252"xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/title | "cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B."xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/title | "cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B."xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15516339 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15516339 |
| http://purl.uniprot.org/citations/15516339 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15516339 |
| http://purl.uniprot.org/citations/15516339 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15516339 |
| http://purl.uniprot.org/citations/15516339 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15516339 |