| http://purl.uniprot.org/citations/15516976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15516976 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic predisposition to cancers is significant to public health because a high proportion of cancers probably arise in a susceptible human subpopulation. Using a mouse model of gamma-ray-induced thymic lymphomas, we performed linkage analysis and haplotype mapping that suggested Mtf-1, metal-responsive transcription factor-1 (Mtf-1), as a candidate lymphoma susceptibility gene. Sequence analysis revealed a polymorphism of Mtf-1 that alters the corresponding amino acid at position 424 in the proline-rich domain from a serine in susceptibility strains to proline in resistant strains. The transcriptional activity of Mtf-1 encoding serine and proline was compared by transfecting the DNA to Mtf-1-null cells, and the change to proline conferred a higher metal responsiveness in transfections. Furthermore, the resistant congenic strains possessing the Mtf-1 allele of proline type exhibited higher radiation inducibility of target genes than susceptible background strains having the Mtf-1 allele of serine type. Since products of the targets such as metallothionein are able to suppress cellular stresses generated by irradiation, these results suggest that highly inducible strains having Mtf-1 of proline type are refractory to radiation effects and hence are resistant to lymphoma development."xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1208197"xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/author | "Mishima Y."xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/author | "Tamura Y."xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/author | "Niwa O."xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/author | "Maruyama M."xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/author | "Fujisawa H."xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/author | "Aoyagi Y."xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/author | "Schaffner W."xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/author | "Kominami R."xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/author | "Kodama Y."xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/author | "Yoshikai Y."xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/author | "Obata M."xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/pages | "399-406"xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/title | "Predisposition to mouse thymic lymphomas in response to ionizing radiation depends on variant alleles encoding metal-responsive transcription factor-1 (Mtf-1)."xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/15516976 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15516976 |
| http://purl.uniprot.org/citations/15516976 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15516976 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDC6-mappedCitation-15516976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15516976 |
| http://purl.uniprot.org/uniprot/#_B1ARW6-mappedCitation-15516976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15516976 |
| http://purl.uniprot.org/uniprot/#_Q8BSY2-mappedCitation-15516976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15516976 |
| http://purl.uniprot.org/uniprot/#_Q07243-mappedCitation-15516976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15516976 |