| http://purl.uniprot.org/citations/15518240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15518240 | http://www.w3.org/2000/01/rdf-schema#comment | "The IGF-II/M6P receptor targets cathepsin D to the lysosomes and it also binds IGF-II. Although the binding sites for IGF-II and cathepsin D are distinct, reciprocal interactions between the ligands have been observed. We have demonstrated that proIGF-II expression modulates routing of cathepsin D. To test the hypothesis that IGF-II modulation of cathepsin D routing in MCF-7 cells involves IGF-II binding to the IGF-II/M6P receptor, we expressed a mutant form of IGF-II (Arg54 Arg55) that does not bind the IGF-II/M6P receptor and evaluated its effects on cathepsin D secretion. Northern blotting, Western and radioimmunoassay analyses confirmed that these cells express high levels of (Arg54 Arg55) IGF-II mRNA and secretes high levels of IGF-II without modulating the secretion of cathepsin D. These data provide direct evidence that the IGF-II modulation of cathepsin D routing is IGF-II/M6P receptor mediated."xsd:string |
| http://purl.uniprot.org/citations/15518240 | http://purl.org/dc/terms/identifier | "doi:10.1080/08977190410001725531"xsd:string |
| http://purl.uniprot.org/citations/15518240 | http://purl.uniprot.org/core/author | "Mohan S."xsd:string |
| http://purl.uniprot.org/citations/15518240 | http://purl.uniprot.org/core/author | "De Leon D.D."xsd:string |
| http://purl.uniprot.org/citations/15518240 | http://purl.uniprot.org/core/author | "Faridi J.S."xsd:string |
| http://purl.uniprot.org/citations/15518240 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15518240 | http://purl.uniprot.org/core/name | "Growth Factors"xsd:string |
| http://purl.uniprot.org/citations/15518240 | http://purl.uniprot.org/core/pages | "169-177"xsd:string |
| http://purl.uniprot.org/citations/15518240 | http://purl.uniprot.org/core/title | "Modulation of cathepsin D routing by IGF-II involves IGF-II binding to IGF-II/M6P receptor in MCF-7 breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/15518240 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/15518240 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15518240 |
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| http://purl.uniprot.org/uniprot/#_B9EKB8-mappedCitation-15518240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15518240 |
| http://purl.uniprot.org/uniprot/#_B0LAD8-mappedCitation-15518240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15518240 |
| http://purl.uniprot.org/uniprot/#_B7ZWC4-mappedCitation-15518240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15518240 |
| http://purl.uniprot.org/uniprot/#_Q3TWR6-mappedCitation-15518240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15518240 |
| http://purl.uniprot.org/uniprot/#_Q3TXL5-mappedCitation-15518240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15518240 |
| http://purl.uniprot.org/uniprot/#_Q05BF3-mappedCitation-15518240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15518240 |
| http://purl.uniprot.org/uniprot/#_Q3U8W5-mappedCitation-15518240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15518240 |
| http://purl.uniprot.org/uniprot/#_P09535-mappedCitation-15518240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15518240 |
| http://purl.uniprot.org/uniprot/#_Q07113-mappedCitation-15518240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15518240 |
| http://purl.uniprot.org/uniprot/#_Q3UC89-mappedCitation-15518240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15518240 |
| http://purl.uniprot.org/uniprot/#_Q3UCD9-mappedCitation-15518240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15518240 |
| http://purl.uniprot.org/uniprot/#_P18242-mappedCitation-15518240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15518240 |