| http://purl.uniprot.org/citations/15522217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15522217 | http://www.w3.org/2000/01/rdf-schema#comment | "The SH2/SH3 adapter proteins of the Crk family are potent signal transducers after receptor tyrosine kinase stimulation with insulin or IGF-1. We have employed a yeast two-hybrid approach and mutational analysis to dissect the capabilities of the insulin receptor and the IGF-I receptor to directly associate with Crk isoforms. Insulin receptor stably recruits full length Crk by association with its SH2 domain in an auto-phosphorylation dependent manner. In contrast, interaction of the IGF-I receptor with the Crk-IISH2 domain was only detectable when Crk-II was truncated in its C-terminal part, indicating the transient nature of this interaction. From these data it can be concluded that members of the insulin receptor family activate Crk proteins in a differential manner."xsd:string |
| http://purl.uniprot.org/citations/15522217 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.10.018"xsd:string |
| http://purl.uniprot.org/citations/15522217 | http://purl.uniprot.org/core/author | "Kiess W."xsd:string |
| http://purl.uniprot.org/citations/15522217 | http://purl.uniprot.org/core/author | "Klammt J."xsd:string |
| http://purl.uniprot.org/citations/15522217 | http://purl.uniprot.org/core/author | "Barnikol-Oettler A."xsd:string |
| http://purl.uniprot.org/citations/15522217 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15522217 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/15522217 | http://purl.uniprot.org/core/pages | "183-190"xsd:string |
| http://purl.uniprot.org/citations/15522217 | http://purl.uniprot.org/core/title | "Mutational analysis of the interaction between insulin receptor and IGF-I receptor with c-Crk and Crk-L in a yeast two-hybrid system."xsd:string |
| http://purl.uniprot.org/citations/15522217 | http://purl.uniprot.org/core/volume | "325"xsd:string |
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