| http://purl.uniprot.org/citations/15522230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15522230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15522230 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucose-dependent insulinotropic polypeptide is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. The glucose-dependent action of GIP on pancreatic beta-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. Use of NMR or X-ray crystallography is vital to determine the three-dimensional structure of the peptide. Therefore, to understand the basic structural requirements for the biological activity of GIP, the solution structure of the major biologically active fragment, GIP(1-30)amide, was investigated by proton NMR spectroscopy and molecular modelling. The structure is characterised by a full length alpha-helical conformation between residues F(6) and A(28). This structural information could play an important role in the design of therapeutic agents based upon GIP receptor agonists."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.10.033"xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.10.033"xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/author | "Malthouse J.P."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/author | "Malthouse J.P."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/author | "Hewage C.M."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/author | "Hewage C.M."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/author | "Alana I."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/author | "Alana I."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/author | "Gault V.A."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/author | "Gault V.A."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/author | "O'Harte F.P."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/author | "O'Harte F.P."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/author | "Parker J.C."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/author | "Parker J.C."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/pages | "281-286"xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/pages | "281-286"xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/title | "NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide."xsd:string |
| http://purl.uniprot.org/citations/15522230 | http://purl.uniprot.org/core/title | "NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide."xsd:string |