| http://purl.uniprot.org/citations/15528197 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15528197 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15528197 | http://www.w3.org/2000/01/rdf-schema#comment | "During development, neuronal identity is determined by a combination of numerous transcription factors. However, the mechanisms of synergistic action of these factors in transcriptional regulation and subsequent cell fate specification are largely unknown. In this study, we identified a novel gene, Corl1, encoding a nuclear protein with homology to the Ski oncoprotein. Corl1 was highly selectively expressed in the central nervous system (CNS). In the embryonic CNS, Corl1 was expressed in a certain subset of postmitotic neurons generated posterior to the midbrain-hindbrain border. In the developing spinal cord, Corl1 was selectively expressed in the dorsal horn interneurons where a homeodomain transcription factor, Lbx1, is required for proper specification. Corl1 was localized in a nuclear dot-like structure and interacted with general transcriptional corepressors. In addition, Corl1 showed transcriptional repression activity in the GAL4-fusion system, indicating its involvement in the regulation of transcriptional repression. Furthermore, Corl1 interacted with Lbx1 and cooperatively repressed transcription, suggesting that it acts as a transcriptional corepressor for Lbx1 in regulating cell fate determination in the dorsal spinal cord. Corl1 corepressor activity did not depend on Gro/TLE activity, and Gro/TLE also functioned as a corepressor for Lbx1. Thus, Lbx1 can select two independent partners, Corl1 and Gro/TLE, as corepressors. Identification of a novel transcriptional corepressor with neuronal subtype-restricted expression might provide insights into the mechanisms of cell fate determination in neurons."xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m411652200"xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m411652200"xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/author | "Ono Y."xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/author | "Ono Y."xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/author | "Sakamoto Y."xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/author | "Sakamoto Y."xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/author | "Nakatani T."xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/author | "Nakatani T."xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/author | "Minaki Y."xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/author | "Minaki Y."xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/author | "Mizuhara E."xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/author | "Mizuhara E."xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/pages | "3645-3655"xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/pages | "3645-3655"xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/title | "Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1."xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/title | "Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1."xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15528197 | http://purl.uniprot.org/core/volume | "280"xsd:string |