| http://purl.uniprot.org/citations/15528234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15528234 | http://www.w3.org/2000/01/rdf-schema#comment | "Decreased beta-adrenergic receptor (beta-AR) number occurs both in animal models of cardiac hypertrophy and failure and in patients. beta-AR recycling is an important mechanism for the beta-AR resensitization that maintains a normal complement of cell surface beta-ARs. We have shown that 1) in severe pressure overload cardiac hypertrophy, there is extensive microtubule-associated protein 4 (MAP4) decoration of a dense microtubule network; and 2) MAP4 microtubule decoration inhibits muscarinic acetylcholine receptor recycling in neuroblastoma cells. We asked here whether MAP4 microtubule decoration inhibits beta-AR recycling in adult cardiocytes. [(3)H]CGP-12177 was used as a beta-AR ligand, and feline cardiocytes were isolated and infected with adenovirus containing MAP4 (AdMAP4) or beta-galactosidase (Adbeta-gal) cDNA. MAP4 decorated the microtubules extensively only in AdMAP4 cardiocytes. beta-AR agonist exposure reduced cell surface beta-AR number comparably in AdMAP4 and Adbeta-gal cardiocytes; however, after agonist withdrawal, the cell surface beta-AR number recovered to 78.4 +/-2.9% of the pretreatment value in Adbeta-gal cardiocytes but only to 56.8 +/-1.4% in AdMAP4 cardiocytes (P < 0.01). This result was confirmed in cardiocytes isolated from transgenic mice having cardiac-restricted MAP4 overexpression. In functional terms of cAMP generation, beta-AR agonist responsiveness of AdMAP4 cells was 47% less than that of Adbeta-gal cells. We conclude that MAP4 microtubule decoration interferes with beta-AR recycling and that this may be one mechanism for beta-AR downregulation in heart failure."xsd:string |
| http://purl.uniprot.org/citations/15528234 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpheart.00109.2004"xsd:string |
| http://purl.uniprot.org/citations/15528234 | http://purl.uniprot.org/core/author | "Cheng G."xsd:string |
| http://purl.uniprot.org/citations/15528234 | http://purl.uniprot.org/core/author | "Gallien T.N."xsd:string |
| http://purl.uniprot.org/citations/15528234 | http://purl.uniprot.org/core/author | "Qiao F."xsd:string |
| http://purl.uniprot.org/citations/15528234 | http://purl.uniprot.org/core/author | "Cooper G."xsd:string |
| http://purl.uniprot.org/citations/15528234 | http://purl.uniprot.org/core/author | "Kuppuswamy D."xsd:string |
| http://purl.uniprot.org/citations/15528234 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15528234 | http://purl.uniprot.org/core/name | "Am J Physiol Heart Circ Physiol"xsd:string |
| http://purl.uniprot.org/citations/15528234 | http://purl.uniprot.org/core/pages | "H1193-202"xsd:string |
| http://purl.uniprot.org/citations/15528234 | http://purl.uniprot.org/core/title | "Inhibition of beta-adrenergic receptor trafficking in adult cardiocytes by MAP4 decoration of microtubules."xsd:string |
| http://purl.uniprot.org/citations/15528234 | http://purl.uniprot.org/core/volume | "288"xsd:string |
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