| http://purl.uniprot.org/citations/15531553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15531553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15531553 | http://www.w3.org/2000/01/rdf-schema#comment | "The lymphoid tyrosine phosphatase (LYP), encoded by the protein tyrosine phosphatase-22 (PTPN22) gene, is a powerful inhibitor of T cell activation. Recently, a single nucleotide polymorphism (SNP), encoding a functional arginine to tryptophan residue change at LYP codon 620 has been shown to be associated with type 1 diabetes and other autoimmune disorders. We have used a PCR-restriction fragment (XcmI) assay to examine genotypes at the codon 620 polymorphism in 549 unrelated probands with Graves' disease, 104 unrelated subjects with autoimmune Addison's disease and 429 controls. The T nucleotide at the SNP, encoding the tryptophan 620 residue, was present in 151 of 1098 (13.8%) Graves' disease alleles compared to 67 of 858 (7.8%) control alleles (chi(2) = 17.2, p = 3.4 x 10(-5)' odds ratio = 1.88, 5-95% confidence intervals [CI] 1.39 to 2.55). Similarly, the T nucleotide at the codon 620 SNP was present in 26 of 208 (12.5%) Addison's disease alleles vs 7.8% of controls (chi(2) = 4.63, p = 0.031; odds ratio = 1.69, 5-95% CI 1.04 to 2.73). These data suggest that this LYP polymorphism is a susceptibility allele for Graves' disease with a major effect, and which is likely to have a role in many other autoimmune conditions."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.org/dc/terms/identifier | "doi:10.1210/jc.2004-1108"xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.org/dc/terms/identifier | "doi:10.1210/jc.2004-1108"xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Ball S.G."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Ball S.G."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Perros P."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Perros P."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Quinton R."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Quinton R."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Wilson V."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Wilson V."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Pearce S.H."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Pearce S.H."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Donaldson P.T."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Donaldson P.T."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Herington S."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Herington S."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "James R.A."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "James R.A."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Jennings C.E."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Jennings C.E."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Owen C.J."xsd:string |
| http://purl.uniprot.org/citations/15531553 | http://purl.uniprot.org/core/author | "Owen C.J."xsd:string |