| http://purl.uniprot.org/citations/15534371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15534371 | http://www.w3.org/2000/01/rdf-schema#comment | "It has been reported that the differentiation of CD4+CD25+ regulatory T cells (T reg cells) can be induced by agonist peptide/major histocompatibility complex ligands in the thymus. Exploiting a transgenic mouse line wherein expression of a particular T cell epitope can be controlled temporally and quantitatively, we found that diversion of differentiating thymocytes into the FoxP3 T reg cell pathway by this agonist ligand was essentially nonexistent. However, CD4+CD25+ thymocytes were much less sensitive than their CD4+CD25-companions, by two to three orders of magnitude, to agonist-induced clonal deletion, such that their proportion increased, giving the false impression of induced differentiation. To account for these and prior observations, one can propose that differentiation along the CD4+CD25+ pathway is induced by cues other than recognition of self-agonist cues, which are poorly read by thymocytes, whose T cell receptors are conducive to selection toward the conventional CD4+CD25-lineage. Thus, selective survival, rather than induced differentiation, may explain the apparent enrichment observed here and in previous studies."xsd:string |
| http://purl.uniprot.org/citations/15534371 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20041022"xsd:string |
| http://purl.uniprot.org/citations/15534371 | http://purl.uniprot.org/core/author | "Benoist C."xsd:string |
| http://purl.uniprot.org/citations/15534371 | http://purl.uniprot.org/core/author | "Mathis D."xsd:string |
| http://purl.uniprot.org/citations/15534371 | http://purl.uniprot.org/core/author | "van Santen H.M."xsd:string |
| http://purl.uniprot.org/citations/15534371 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15534371 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/15534371 | http://purl.uniprot.org/core/pages | "1221-1230"xsd:string |
| http://purl.uniprot.org/citations/15534371 | http://purl.uniprot.org/core/title | "Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/15534371 | http://purl.uniprot.org/core/volume | "200"xsd:string |
| http://purl.uniprot.org/citations/15534371 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15534371 |
| http://purl.uniprot.org/citations/15534371 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15534371 |
| http://purl.uniprot.org/uniprot/#_Q3U4Q8-mappedCitation-15534371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15534371 |
| http://purl.uniprot.org/uniprot/#_P04441-mappedCitation-15534371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15534371 |
| http://purl.uniprot.org/uniprot/#_Q545Y5-mappedCitation-15534371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15534371 |
| http://purl.uniprot.org/uniprot/Q545Y5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15534371 |
| http://purl.uniprot.org/uniprot/P04441 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15534371 |
| http://purl.uniprot.org/uniprot/Q3U4Q8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15534371 |