| http://purl.uniprot.org/citations/15536192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15536192 | http://www.w3.org/2000/01/rdf-schema#comment | "CXCR4, the stromal cell-derived factor-1 receptor, plays an important role in the migration of hematopoietic progenitor/stem cells. The surface and cytoplasmic expression of CXCR4 on human hematopoietic CD34(+) cells was investigated. We show that its surface expression is low, whereas a large part of CXCR4 protein is sequestered intracellularly. Using confocal microscopy, we demonstrated that CXCR4 is colocalized with EEA-1, Rab5, Rab4, and Rab11, which are localized in early and recycling endosomes. No significant colocalization of CXCR4 with lysosomal markers CD63 and Lamp-1 was detected. Using antibody feeding experiments, we report a role for CXCR4 constitutive endocytosis in subcellular localization in stably transduced UT7-CXCR4-GFP and CD34(+) cells. Agonist-independent endocytosis of CXCR4 occurs through clathrin-coated vesicles. These data implicate a constitutive endocytosis in the regulation of CXCR4 membrane expression and suggest that constitutive endocytosis may be involved in the regulation of trafficking the human hematopoietic progenitor/stem cells to and in the bone marrow microenvironment."xsd:string |
| http://purl.uniprot.org/citations/15536192 | http://purl.org/dc/terms/identifier | "doi:10.1634/stemcells.22-6-1015"xsd:string |
| http://purl.uniprot.org/citations/15536192 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/15536192 | http://purl.uniprot.org/core/author | "Jalil A."xsd:string |
| http://purl.uniprot.org/citations/15536192 | http://purl.uniprot.org/core/author | "Louache F."xsd:string |
| http://purl.uniprot.org/citations/15536192 | http://purl.uniprot.org/core/author | "Vainchenker W."xsd:string |
| http://purl.uniprot.org/citations/15536192 | http://purl.uniprot.org/core/author | "Buet D."xsd:string |
| http://purl.uniprot.org/citations/15536192 | http://purl.uniprot.org/core/author | "Foudi A."xsd:string |
| http://purl.uniprot.org/citations/15536192 | http://purl.uniprot.org/core/author | "Berthebaud M."xsd:string |
| http://purl.uniprot.org/citations/15536192 | http://purl.uniprot.org/core/author | "Geay J.F."xsd:string |
| http://purl.uniprot.org/citations/15536192 | http://purl.uniprot.org/core/author | "Jarrier P."xsd:string |
| http://purl.uniprot.org/citations/15536192 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15536192 | http://purl.uniprot.org/core/name | "Stem Cells"xsd:string |
| http://purl.uniprot.org/citations/15536192 | http://purl.uniprot.org/core/pages | "1015-1029"xsd:string |
| http://purl.uniprot.org/citations/15536192 | http://purl.uniprot.org/core/title | "Intracellular localization and constitutive endocytosis of CXCR4 in human CD34+ hematopoietic progenitor cells."xsd:string |
| http://purl.uniprot.org/citations/15536192 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/15536192 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15536192 |
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