| http://purl.uniprot.org/citations/15537897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15537897 | http://www.w3.org/2000/01/rdf-schema#comment | "Interactions between NMDA receptors (NMDARs) and the PDZ [postsynaptic density-95 (PSD-95)/Discs large/zona occludens-1] domains of PSD-95/SAP90 (synapse-associated protein with a molecular weight of 90 kDa) family proteins play important roles in the synaptic targeting and signaling of NMDARs. However, little is known about the mechanisms that regulate these PDZ domain-mediated interactions. Here we show that casein kinase II (CK2) phosphorylates the serine residue (Ser1480) within the C-terminal PDZ ligand (IESDV) of the NR2B subunit of NMDAR in vitro and in vivo. Phosphorylation of Ser1480 disrupts the interaction of NR2B with the PDZ domains of PSD-95 and SAP102 and decreases surface NR2B expression in neurons. Interestingly, activity of the NMDAR and Ca2+/calmodulin-dependent protein kinase II regulates CK2 phosphorylation of Ser1480. Furthermore, CK2 colocalizes with NR1 and PSD-95 at synaptic sites. These results indicate that activity-dependent CK2 phosphorylation of the NR2B PDZ ligand regulates the interaction of NMDAR with PSD-95/SAP90 family proteins as well as surface NMDAR expression and may be a critical mechanism for modulating excitatory synaptic function and plasticity."xsd:string |
| http://purl.uniprot.org/citations/15537897 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.0546-04.2004"xsd:string |
| http://purl.uniprot.org/citations/15537897 | http://purl.uniprot.org/core/author | "Chung H.J."xsd:string |
| http://purl.uniprot.org/citations/15537897 | http://purl.uniprot.org/core/author | "Huang Y.H."xsd:string |
| http://purl.uniprot.org/citations/15537897 | http://purl.uniprot.org/core/author | "Huganir R.L."xsd:string |
| http://purl.uniprot.org/citations/15537897 | http://purl.uniprot.org/core/author | "Lau L.F."xsd:string |
| http://purl.uniprot.org/citations/15537897 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15537897 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/15537897 | http://purl.uniprot.org/core/pages | "10248-10259"xsd:string |
| http://purl.uniprot.org/citations/15537897 | http://purl.uniprot.org/core/title | "Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand."xsd:string |
| http://purl.uniprot.org/citations/15537897 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/15537897 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15537897 |
| http://purl.uniprot.org/citations/15537897 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15537897 |
| http://purl.uniprot.org/uniprot/#_A6KTU1-mappedCitation-15537897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15537897 |
| http://purl.uniprot.org/uniprot/#_A6KTU4-mappedCitation-15537897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15537897 |
| http://purl.uniprot.org/uniprot/#_A0A8L2UP98-mappedCitation-15537897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15537897 |
| http://purl.uniprot.org/uniprot/#_N0E459-mappedCitation-15537897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15537897 |
| http://purl.uniprot.org/uniprot/#_N0E4B7-mappedCitation-15537897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15537897 |
| http://purl.uniprot.org/uniprot/#_N0E631-mappedCitation-15537897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15537897 |
| http://purl.uniprot.org/uniprot/#_P67874-mappedCitation-15537897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15537897 |
| http://purl.uniprot.org/uniprot/#_Q00960-mappedCitation-15537897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15537897 |
| http://purl.uniprot.org/uniprot/#_Q68G11-mappedCitation-15537897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15537897 |
| http://purl.uniprot.org/uniprot/N0E459 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15537897 |
| http://purl.uniprot.org/uniprot/P67874 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15537897 |