| http://purl.uniprot.org/citations/15540986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15540986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15540986 | http://www.w3.org/2000/01/rdf-schema#comment | "CD43 is a transmembrane molecule that contains a 123-aminoacids-long cytoplasmic tail and a highly O-glycosylated extracellular domain of mucin type. Endogenous CD43 expressed in COLO 205, K562 and Jurkat cells revealed a membrane-associated, 20 kDa CD43-specific cytoplasmic tail fragment (CD43-CTF) upon inhibition of gamma-secretase. This fragment was formed by an extracellular cleavage, as it was not accumulated after treating cells with 1,10-phenanthroline, a metalloprotease inhibitor. When CD43 was transfected into HEK-293 cells expressing dominant-negative PS1 (presenilin-1), the CD43-CTF was accumulated, but not in cells with wild-type PS1. Owing to its accumulation in the presence of a non-functional PS variant, it may thus be a novel gamma-secretase substrate. This CTF is formed by an extracellular cleavage close to the membrane, is a fragment that can be concluded to be a substrate for gamma-secretase. However, the intracellular gamma-secretase product has not been possible to detect, suggesting a quick processing of this product. During normal growth the CTF was not found without gamma-secretase inhibition, but when the cells (COLO 205) were very confluent the fragment could be detected. The intracellular domain of CD43 has previously been shown to contain a functional nuclear localization signal, and has been suggested to be involved in gene activation. From this and the present results, a novel way to explain how mucin-type molecules may transduce intracellular signals can be proposed."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20041387"xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20041387"xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/author | "Haass C."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/author | "Haass C."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/author | "Andersson C.X."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/author | "Andersson C.X."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/author | "Hansson G.C."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/author | "Hansson G.C."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/author | "Baeckstroem D."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/author | "Baeckstroem D."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/author | "Fernandez-Rodriguez J."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/author | "Fernandez-Rodriguez J."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/author | "Laos S."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/author | "Laos S."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/pages | "377-384"xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/pages | "377-384"xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/title | "Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43."xsd:string |
| http://purl.uniprot.org/citations/15540986 | http://purl.uniprot.org/core/title | "Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43."xsd:string |