| http://purl.uniprot.org/citations/15541354 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15541354 | http://www.w3.org/2000/01/rdf-schema#comment | "The chemokine receptors CCR5 and CXCR4 belong to the family of seven transmembrane-spanning G protein-coupled receptors, which have diverse functions in host cell defense and are associated with numerous diseases. CCR5 and CXCR4 are known as co-receptors for entry of HIV-1. In this study the intracellular carboxy-terminus of CCR5, which is deleted in HIV-infected long-term non-progressors, was shown to interact with the carboxy-terminus of alpha-catenin, a component of the cytoskeleton, in a yeast two-hybrid screen. This interaction was verified in mammalian cells. Furthermore, the interaction of alpha-catenin with CCR5 and CXCR4 at endogenous protein levels was demonstrated in PM1 T-lymphocytes, a host cell line of HIV-1. Our results suggest that alpha-catenin links CCR5 and CXCR4 to the cytoskeleton and is involved in the organization of these receptors at the membrane, thereby possibly affecting HIV-1 infection."xsd:string |
| http://purl.uniprot.org/citations/15541354 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.10.096"xsd:string |
| http://purl.uniprot.org/citations/15541354 | http://purl.uniprot.org/core/author | "Moelling K."xsd:string |
| http://purl.uniprot.org/citations/15541354 | http://purl.uniprot.org/core/author | "Bachmann A.S."xsd:string |
| http://purl.uniprot.org/citations/15541354 | http://purl.uniprot.org/core/author | "Schweneker M."xsd:string |
| http://purl.uniprot.org/citations/15541354 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15541354 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/15541354 | http://purl.uniprot.org/core/pages | "751-757"xsd:string |
| http://purl.uniprot.org/citations/15541354 | http://purl.uniprot.org/core/title | "The HIV-1 co-receptor CCR5 binds to alpha-catenin, a component of the cellular cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/15541354 | http://purl.uniprot.org/core/volume | "325"xsd:string |
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