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http://purl.uniprot.org/citations/15541366http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15541366http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15541366http://www.w3.org/2000/01/rdf-schema#comment"p73 is a transcriptional activator related to tumor suppressor p53 and regulates differentiation, cell-cycle arrest, and apoptosis. Recently, zebrafish p73 (zp73alpha) was isolated and shown to be required for zebrafish embryogenesis. In this study, we isolated a novel splicing-variant of zp73 mRNA, which was generated by the use of an alternative splicing acceptor site, and designated it as zp73theta;. The zp73theta; mRNA encoded a carboxy-terminal structure distinct from that of zp73alpha. Whereas the expression level of zp73theta; mRNA was much lower than that of zp73alpha in zebrafish adult tissues, it was relatively high and fluctuated during embryogenesis. Using Saos-2 cells for a transient reporter assay, we found that zp73theta;, but not zp73alpha, had strong transcriptional activity when the experiments were performed at 34 degrees C. In addition, zp73theta; had the ability to suppress the growth of Saos-2 cells and to cause the developmental defects in zebrafish. These data indicated that zp73theta; could work as a transcriptional activator in zebrafish."xsd:string
http://purl.uniprot.org/citations/15541366http://purl.org/dc/terms/identifier"doi:10.1016/j.bbrc.2004.10.109"xsd:string
http://purl.uniprot.org/citations/15541366http://purl.org/dc/terms/identifier"doi:10.1016/j.bbrc.2004.10.109"xsd:string
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/author"Arai K."xsd:string
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/author"Arai K."xsd:string
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/author"Watanabe S."xsd:string
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/author"Watanabe S."xsd:string
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/author"Satoh S."xsd:string
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/author"Satoh S."xsd:string
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/name"Biochem Biophys Res Commun"xsd:string
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/pages"835-842"xsd:string
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/pages"835-842"xsd:string
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/title"Identification of a novel splicing form of zebrafish p73 having a strong transcriptional activity."xsd:string
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/title"Identification of a novel splicing form of zebrafish p73 having a strong transcriptional activity."xsd:string
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/volume"325"xsd:string
http://purl.uniprot.org/citations/15541366http://purl.uniprot.org/core/volume"325"xsd:string
http://purl.uniprot.org/citations/15541366http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15541366
http://purl.uniprot.org/citations/15541366http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15541366
http://purl.uniprot.org/citations/15541366http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15541366
http://purl.uniprot.org/citations/15541366http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15541366