| http://purl.uniprot.org/citations/15542594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15542594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15542594 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular endothelial growth factor-A (VEGF-A(165)) exerts multiple effects upon binding to the fms-like tyrosine kinase-1 (Flt-1) and the kinase insert domain-containing receptor (KDR). We recently identified two novel snake venom VEGFs (vammin and VR-1) having unique properties. These VEGFs, designated VEGF-Fs, are highly specific ligands for the kinase insert domain-containing receptor and exhibit potent biological activity both in vitro and in vivo when compared with VEGF-A(165). Here, we solved the crystal structures of vammin and VR-1 at 1.9 and 2.0 A resolutions, respectively. Both structures are very similar to each other, and these structures exhibit similar but significantly different features from the known structures of other VEGFs. These differences include a conformational difference in receptor-binding loop 3 caused by an amino acid residue insertion and a difference in surface potential on the possible binding surface for domain 3 of the receptor. These structural differences may be related to the highly selective ligand properties of VEGF-F."xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m411395200"xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m411395200"xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/author | "Morita T."xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/author | "Morita T."xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/author | "Mizuno H."xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/author | "Mizuno H."xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/author | "Yamazaki Y."xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/author | "Yamazaki Y."xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/author | "Suto K."xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/author | "Suto K."xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/pages | "2126-2131"xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/pages | "2126-2131"xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/title | "Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1."xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/title | "Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1."xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15542594 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15542594 |
| http://purl.uniprot.org/citations/15542594 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15542594 |