| http://purl.uniprot.org/citations/15542853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15542853 | http://www.w3.org/2000/01/rdf-schema#comment | "Deregulated function of members of the POK (POZ and Kruppel) family of transcriptional repressors, such as promyelocytic leukemia zinc finger (PLZF) and B-cell lymphoma 6 (BCL-6), plays a critical role in the pathogenesis of acute promyelocytic leukemia (APL) and non-Hodgkin's lymphoma, respectively. PLZP, also known as TZFP, FAZF, or ROG, is a novel POK protein that displays strong homology with PLZF and has been implicated in the pathogenesis of the cancer-predisposing syndrome, Fanconi's anemia, and of APL, in view of its ability to heterodimerize with the FANC-C and PLZF proteins, respectively. Here we report the generation and characterization of mice in which we have specifically inactivated the PLZP gene through in-frame insertion of a lacZ reporter and without perturbing the expression of the neighboring MLL2 gene. We show that PLZP-deficient mice display defects in cell cycle control and cytokine production in the T-cell compartment. Importantly, PLZP inactivation perturbs the homeostasis of the hematopoietic stem and/or progenitor cell. On the basis of our data, a deregulation of PLZP function in Fanconi's anemia and APL may affect the biology of the hematopoietic stem cell, in turn contributing to the pathogenesis of these disorders."xsd:string |
| http://purl.uniprot.org/citations/15542853 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.23.10456-10469.2004"xsd:string |
| http://purl.uniprot.org/citations/15542853 | http://purl.uniprot.org/core/author | "Hobbs R.M."xsd:string |
| http://purl.uniprot.org/citations/15542853 | http://purl.uniprot.org/core/author | "Pandolfi P.P."xsd:string |
| http://purl.uniprot.org/citations/15542853 | http://purl.uniprot.org/core/author | "Piazza F."xsd:string |
| http://purl.uniprot.org/citations/15542853 | http://purl.uniprot.org/core/author | "Merghoub T."xsd:string |
| http://purl.uniprot.org/citations/15542853 | http://purl.uniprot.org/core/author | "Costoya J.A."xsd:string |
| http://purl.uniprot.org/citations/15542853 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15542853 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/15542853 | http://purl.uniprot.org/core/pages | "10456-10469"xsd:string |
| http://purl.uniprot.org/citations/15542853 | http://purl.uniprot.org/core/title | "Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis."xsd:string |
| http://purl.uniprot.org/citations/15542853 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/15542853 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15542853 |
| http://purl.uniprot.org/citations/15542853 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15542853 |
| http://purl.uniprot.org/uniprot/Q9JKD9#attribution-925BB3498941B3011BB2B30A86B059E3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15542853 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY77-mappedCitation-15542853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15542853 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQ73-mappedCitation-15542853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15542853 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHD4-mappedCitation-15542853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15542853 |
| http://purl.uniprot.org/uniprot/#_B2RQ06-mappedCitation-15542853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15542853 |
| http://purl.uniprot.org/uniprot/#_Q6PDK2-mappedCitation-15542853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15542853 |
| http://purl.uniprot.org/uniprot/#_Q3USG3-mappedCitation-15542853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15542853 |
| http://purl.uniprot.org/uniprot/#_Q3USM7-mappedCitation-15542853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15542853 |
| http://purl.uniprot.org/uniprot/#_Q9JKD9-mappedCitation-15542853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15542853 |
| http://purl.uniprot.org/uniprot/#_Q99P40-mappedCitation-15542853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15542853 |