| http://purl.uniprot.org/citations/15543135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15543135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15543135 | http://www.w3.org/2000/01/rdf-schema#comment | "The synaptotagmin-like protein (Slp) family is implicated in regulating Rab27A-mediated membrane transport, but how it might do this is unknown. Here we report that Slp2-a, a previously uncharacterized Rab27A-binding protein in melanocytes, controls melanosome distribution in the cell periphery and regulates the morphology of melanocytes. Slp2-a is the most abundantly expressed of the Slp- and Slac2-family proteins in melanocytes and colocalizes with Rab27A on melanosomes. Knockdown of endogenous Slp2-a protein by small-interfering RNAs (siRNAs) markedly reduced the number of melanosomes in the cell periphery of mouse melanocytes ('peripheral dilution'). Expression of siRNA-resistant Slp2-a (Slp2-a(SR)) rescued the peripheral dilution of melanosomes induced by Slp2-a siRNAs, but Slp2-a(SR) mutants, which failed to interact with either phospholipids or Rab27A, did not. Loss of Slp2-a protein also induced a change in melanocyte morphology, from their normal elongated shape to a more rounded shape, which depended on the phospholipid-binding activity of Slp2-a, but not on its Rab27A-binding activity. By contrast, knockdown of Slac2-a (also called melanophilin), another Rab27A-binding protein in melanocytes, caused perinuclear aggregation of melanosomes alone without altering cell shape. These results reveal the differential and sequential roles of Rab27A-binding proteins in melanosome transport in melanocytes."xsd:string |
| http://purl.uniprot.org/citations/15543135 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1197"xsd:string |
| http://purl.uniprot.org/citations/15543135 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1197"xsd:string |
| http://purl.uniprot.org/citations/15543135 | http://purl.uniprot.org/core/author | "Fukuda M."xsd:string |
| http://purl.uniprot.org/citations/15543135 | http://purl.uniprot.org/core/author | "Fukuda M."xsd:string |
| http://purl.uniprot.org/citations/15543135 | http://purl.uniprot.org/core/author | "Kuroda T.S."xsd:string |
| http://purl.uniprot.org/citations/15543135 | http://purl.uniprot.org/core/author | "Kuroda T.S."xsd:string |
| http://purl.uniprot.org/citations/15543135 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15543135 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15543135 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/15543135 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/15543135 | http://purl.uniprot.org/core/pages | "1195-1203"xsd:string |
| http://purl.uniprot.org/citations/15543135 | http://purl.uniprot.org/core/pages | "1195-1203"xsd:string |
| http://purl.uniprot.org/citations/15543135 | http://purl.uniprot.org/core/title | "Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes."xsd:string |
| http://purl.uniprot.org/citations/15543135 | http://purl.uniprot.org/core/title | "Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes."xsd:string |
| http://purl.uniprot.org/citations/15543135 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/15543135 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/15543135 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15543135 |
| http://purl.uniprot.org/citations/15543135 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15543135 |
| http://purl.uniprot.org/citations/15543135 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15543135 |
| http://purl.uniprot.org/citations/15543135 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15543135 |
| http://purl.uniprot.org/uniprot/Q99N50 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15543135 |
| http://purl.uniprot.org/uniprot/Q99N50#attribution-67B015F96C9E6F78C8C867B406BD5176 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15543135 |