| http://purl.uniprot.org/citations/15545601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15545601 | http://www.w3.org/2000/01/rdf-schema#comment | "The Ras signaling pathway plays a critical role in B lymphocyte development and activation, but its activation mechanism has not been well understood. At least one mode of Ras regulation in B cells involves a Ras-guanyl nucleotide exchange factor, RasGRP3. We demonstrate here that RasGRP3 undergoes phosphorylation at Thr-133 upon B cell receptor cross-linking, thereby resulting in its activation. Deletion of phospholipase C-gamma2 or pharmacological interference with conventional PKCs resulted in marked reduction in both Thr-133 phosphorylation and Ras activation. Moreover, mutation of Thr-133 in RasGRP3 alone severely impaired its ability to activate Ras in B cell receptor signaling. Hence, our data suggest that PKC, after being activated by diacylglycerol, phosphorylates RasGRP3, thereby contributing to its full activation."xsd:string |
| http://purl.uniprot.org/citations/15545601 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0407468101"xsd:string |
| http://purl.uniprot.org/citations/15545601 | http://purl.uniprot.org/core/author | "Kimura Y."xsd:string |
| http://purl.uniprot.org/citations/15545601 | http://purl.uniprot.org/core/author | "Mori Y."xsd:string |
| http://purl.uniprot.org/citations/15545601 | http://purl.uniprot.org/core/author | "Kurosaki T."xsd:string |
| http://purl.uniprot.org/citations/15545601 | http://purl.uniprot.org/core/author | "Aiba Y."xsd:string |
| http://purl.uniprot.org/citations/15545601 | http://purl.uniprot.org/core/author | "Hijikata A."xsd:string |
| http://purl.uniprot.org/citations/15545601 | http://purl.uniprot.org/core/author | "Kiyonaka S."xsd:string |
| http://purl.uniprot.org/citations/15545601 | http://purl.uniprot.org/core/author | "Oh-hora M."xsd:string |
| http://purl.uniprot.org/citations/15545601 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15545601 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/15545601 | http://purl.uniprot.org/core/pages | "16612-16617"xsd:string |
| http://purl.uniprot.org/citations/15545601 | http://purl.uniprot.org/core/title | "Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation."xsd:string |
| http://purl.uniprot.org/citations/15545601 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/15545601 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15545601 |
| http://purl.uniprot.org/citations/15545601 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15545601 |
| http://purl.uniprot.org/uniprot/P68404#attribution-975A56E533596AADE673707EF76ABAC9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15545601 |
| http://purl.uniprot.org/uniprot/A0A3Q4EC09#attribution-975A56E533596AADE673707EF76ABAC9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15545601 |
| http://purl.uniprot.org/uniprot/Q69ZX7#attribution-975A56E533596AADE673707EF76ABAC9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15545601 |
| http://purl.uniprot.org/uniprot/Q2PHE9#attribution-975A56E533596AADE673707EF76ABAC9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15545601 |
| http://purl.uniprot.org/uniprot/A0A3Q4EG32#attribution-975A56E533596AADE673707EF76ABAC9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15545601 |
| http://purl.uniprot.org/uniprot/Q6NZH9#attribution-975A56E533596AADE673707EF76ABAC9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15545601 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC09-mappedCitation-15545601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15545601 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EG32-mappedCitation-15545601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15545601 |