| http://purl.uniprot.org/citations/15546618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15546618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15546618 | http://www.w3.org/2000/01/rdf-schema#comment | "Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that eliminates mRNAs containing premature termination codons (PTCs). The proteins UPF1, SMG5, SMG6, and SMG7 are essential NMD factors in metazoa. SMG5 and SMG7 form a complex with UPF1 and interact with each other via their N-terminal domains. Here we show that SMG5 and SMG7 colocalize in cytoplasmic mRNA decay bodies, while SMG6 forms separate cytoplasmic foci. When SMG7 is tethered to a reporter transcript, it elicits its degradation, bypassing the requirement for a PTC, UPF1, SMG5, or SMG6. This activity is mediated by the C-terminal domain of SMG7. In contrast, SMG5 requires SMG7 to trigger mRNA decay and to localize to decay bodies. Our findings indicate that SMG7 provides a link between the NMD and the mRNA degradation machinery by interacting with SMG5 and UPF1 via its N-terminal domain and targeting bound transcripts for decay via its C-terminal domain."xsd:string |
| http://purl.uniprot.org/citations/15546618 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2004.10.013"xsd:string |
| http://purl.uniprot.org/citations/15546618 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2004.10.013"xsd:string |
| http://purl.uniprot.org/citations/15546618 | http://purl.uniprot.org/core/author | "Izaurralde E."xsd:string |
| http://purl.uniprot.org/citations/15546618 | http://purl.uniprot.org/core/author | "Izaurralde E."xsd:string |
| http://purl.uniprot.org/citations/15546618 | http://purl.uniprot.org/core/author | "Unterholzner L."xsd:string |
| http://purl.uniprot.org/citations/15546618 | http://purl.uniprot.org/core/author | "Unterholzner L."xsd:string |
| http://purl.uniprot.org/citations/15546618 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15546618 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15546618 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15546618 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15546618 | http://purl.uniprot.org/core/pages | "587-596"xsd:string |
| http://purl.uniprot.org/citations/15546618 | http://purl.uniprot.org/core/pages | "587-596"xsd:string |
| http://purl.uniprot.org/citations/15546618 | http://purl.uniprot.org/core/title | "SMG7 acts as a molecular link between mRNA surveillance and mRNA decay."xsd:string |
| http://purl.uniprot.org/citations/15546618 | http://purl.uniprot.org/core/title | "SMG7 acts as a molecular link between mRNA surveillance and mRNA decay."xsd:string |
| http://purl.uniprot.org/citations/15546618 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/15546618 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/15546618 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15546618 |
| http://purl.uniprot.org/citations/15546618 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15546618 |
| http://purl.uniprot.org/citations/15546618 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15546618 |
| http://purl.uniprot.org/citations/15546618 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15546618 |
| http://purl.uniprot.org/uniprot/Q92540 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15546618 |
| http://purl.uniprot.org/uniprot/Q9UPR3 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15546618 |