| http://purl.uniprot.org/citations/15549727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15549727 | http://www.w3.org/2000/01/rdf-schema#comment | "Expulsion of the gastrointestinal nematode Trichuris muris is mediated by a T helper (Th)2-type response, involving interleukin (IL)-4, IL-9 and IL-13. Here, we show that Th2 response-associated resistance is dependent on the presence of IL-1alpha and IL-1beta. When lymph node cells from naive IL-1alpha- or IL-1beta-deficient mice were subjected to Th2 polarization in vitro, they failed to polarize in the presence of IL-4 alone, but required the addition of exogenous IL-1alpha or IL-1beta. Furthermore, we demonstrate that both IL-1alpha- and IL-1beta-deficient mice are susceptible to chronic T. muris infection and that the inability to expel the worms is associated with a defect in the development of a Th2 response in the mesenteric lymph nodes. These results provide the first demonstration of the critical role of IL-1 in regulating Th2 responses during gastrointestinal nematode infection."xsd:string |
| http://purl.uniprot.org/citations/15549727 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200425452"xsd:string |
| http://purl.uniprot.org/citations/15549727 | http://purl.uniprot.org/core/author | "Helmby H."xsd:string |
| http://purl.uniprot.org/citations/15549727 | http://purl.uniprot.org/core/author | "Grencis R.K."xsd:string |
| http://purl.uniprot.org/citations/15549727 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15549727 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15549727 | http://purl.uniprot.org/core/pages | "3674-3681"xsd:string |
| http://purl.uniprot.org/citations/15549727 | http://purl.uniprot.org/core/title | "Interleukin 1 plays a major role in the development of Th2-mediated immunity."xsd:string |
| http://purl.uniprot.org/citations/15549727 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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