| http://purl.uniprot.org/citations/15549733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15549733 | http://www.w3.org/2000/01/rdf-schema#comment | "Eosinophil infiltration of the lung is a feature of both allergic and nonallergic asthma, and IL-5 is the key cytokine regulating the production and activation of these cells. Despite many studies focusing on the IL-5 promoter in both humans and mice there is as yet no clear picture of how the IL-5 gene is regulated. The aim of this study was to determine if distal regulatory elements contribute to appropriate regulation of the human IL-5 (hIL-5) gene. Activity of the -507/+44 hIL-5 promoter was compared to expression of the endogenous IL-5 gene in PER-117 T cells. The IL-5 promoter was not sufficient to reproduce a physiological pattern of IL-5 expression. Further, functional analysis of the 5' and 3' intergenic regions revealed a number of novel regulatory elements. We have identified a conserved enhancer located approximately 6.2 kb upstream of the hIL-5 gene. This region contains two potential GATA-3-binding sites and increases expression from the hIL-5 promoter by up to ninefold."xsd:string |
| http://purl.uniprot.org/citations/15549733 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200425279"xsd:string |
| http://purl.uniprot.org/citations/15549733 | http://purl.uniprot.org/core/author | "Urwin D.L."xsd:string |
| http://purl.uniprot.org/citations/15549733 | http://purl.uniprot.org/core/author | "Groth D.M."xsd:string |
| http://purl.uniprot.org/citations/15549733 | http://purl.uniprot.org/core/author | "Sanderson C.J."xsd:string |
| http://purl.uniprot.org/citations/15549733 | http://purl.uniprot.org/core/author | "Schwenger G.T."xsd:string |
| http://purl.uniprot.org/citations/15549733 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15549733 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15549733 | http://purl.uniprot.org/core/pages | "3633-3643"xsd:string |
| http://purl.uniprot.org/citations/15549733 | http://purl.uniprot.org/core/title | "Distal regulatory elements play an important role in regulation of the human IL-5 gene."xsd:string |
| http://purl.uniprot.org/citations/15549733 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/15549733 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15549733 |
| http://purl.uniprot.org/citations/15549733 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15549733 |
| http://purl.uniprot.org/uniprot/#_P05113-mappedCitation-15549733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15549733 |
| http://purl.uniprot.org/uniprot/P05113 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15549733 |