| http://purl.uniprot.org/citations/15550251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15550251 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal plasticity relies on tightly regulated control of protein levels at synapses. One mechanism to control protein abundance is the ubiquitin-proteasome degradation system. Recent studies have implicated ubiquitin-mediated protein degradation in synaptic development, function, and plasticity, but little is known about the regulatory mechanisms controlling ubiquitylation in neurons. In contrast, ubiquitylation has long been studied as a central regulator of the eukaryotic cell cycle. A critical mediator of cell-cycle transitions, the anaphase-promoting complex/cyclosome (APC/C), is an E3 ubiquitin ligase. Although the APC/C has been detected in several differentiated cell types, a functional role for the complex in postmitotic cells has been elusive. We describe a novel postmitotic role for the APC/C at Drosophila neuromuscular synapses: independent regulation of synaptic growth and synaptic transmission. In neurons, the APC/C controls synaptic size via a downstream effector Liprin-alpha; in muscles, the APC/C regulates synaptic transmission, controlling the concentration of a postsynaptic glutamate receptor."xsd:string |
| http://purl.uniprot.org/citations/15550251 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.11.028"xsd:string |
| http://purl.uniprot.org/citations/15550251 | http://purl.uniprot.org/core/author | "Brand A.H."xsd:string |
| http://purl.uniprot.org/citations/15550251 | http://purl.uniprot.org/core/author | "Elliott D.A."xsd:string |
| http://purl.uniprot.org/citations/15550251 | http://purl.uniprot.org/core/author | "Prokop A."xsd:string |
| http://purl.uniprot.org/citations/15550251 | http://purl.uniprot.org/core/author | "Robinson I.M."xsd:string |
| http://purl.uniprot.org/citations/15550251 | http://purl.uniprot.org/core/author | "van Roessel P."xsd:string |
| http://purl.uniprot.org/citations/15550251 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15550251 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/15550251 | http://purl.uniprot.org/core/pages | "707-718"xsd:string |
| http://purl.uniprot.org/citations/15550251 | http://purl.uniprot.org/core/title | "Independent regulation of synaptic size and activity by the anaphase-promoting complex."xsd:string |
| http://purl.uniprot.org/citations/15550251 | http://purl.uniprot.org/core/volume | "119"xsd:string |
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