| http://purl.uniprot.org/citations/15556297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15556297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15556297 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified a novel nucleolar protein, PAP-1-associated protein-1 (PAPA-1), after screening the interacting proteins with Pim-1-associated protein-1 (PAP-1), a protein that is a phosphorylation target of Pim-1 kinase. PAPA-1 comprises 345 amino acids with a basic amino-acid cluster. PAPA-1 was found to be localized in the nucleolus in transfected HeLa cells, and the lysine/histidine cluster was essential for nucleolar localization of PAPA-1. PAPA-1 protein and mRNA expression decreased upon serum restimulation of starvation-synchronized cells, which displayed maximum level of PAPA-1 expression at G0 and early G1 phase of the cell cycle. Ectopic expression of PAPA-1 induced growth suppression of cells, and the effect was dependent on its nucleolar localization in established HeLa cell lines that inducibly express PAPA-1 or its deletion mutant under the control of a tetracycline-inducible promoter. Furthermore, when PAPA-1-inducible HeLa cells were synchronized by thymidine, colcemid or mimosine, and then PAPA-1 was expressed, the proportion of cells at the G1 phase was obviously increased. These results suggest that PAPA-1 induces growth and cell cycle arrests at the G1 phase of the cell cycle."xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2004.05.025"xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2004.05.025"xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/author | "Kitaura H."xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/author | "Kitaura H."xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/author | "Ariga H."xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/author | "Ariga H."xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/author | "Iguchi-Ariga S.M.M."xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/author | "Iguchi-Ariga S.M.M."xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/author | "Taira T."xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/author | "Taira T."xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/author | "Tabata T."xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/author | "Tabata T."xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/author | "Maita H."xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/author | "Maita H."xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/author | "Kuroda T.S."xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/author | "Kuroda T.S."xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/pages | "83-98"xsd:string |
| http://purl.uniprot.org/citations/15556297 | http://purl.uniprot.org/core/pages | "83-98"xsd:string |