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| http://purl.uniprot.org/citations/15556931 | http://www.w3.org/2000/01/rdf-schema#comment | "Parkinson's disease is a common neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of the protein alpha-synuclein into aggregates called Lewy bodies and Lewy neurites. Parkinson's disease can be modeled in Drosophila where directed expression of alpha-synuclein induces compromise of dopaminergic neurons and the formation of Lewy body-like aggregates. The molecular chaperone Hsp70 protects cells from the deleterious effects of alpha-synuclein, indicating a potential therapeutic approach to enhance neuron survival in Parkinson's disease. We have now investigated the molecular mechanisms by which the drug geldanamycin protects neurons against alpha-synuclein toxicity. Our studies show that geldanamycin sensitizes the stress response within normal physiological parameters to enhance chaperone activation, offering protection against alpha-synuclein neurotoxicity. Further, geldanamycin uncouples neuronal toxicity from Lewy body and Lewy neurite formation such that dopaminergic neurons are protected from the effects of alpha-synuclein expression despite the continued presence of (and even increase in) inclusion pathology. These studies indicate that compounds that modulate the stress response are a promising approach to treat Parkinson's disease."xsd:string |
| http://purl.uniprot.org/citations/15556931 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m412106200"xsd:string |
| http://purl.uniprot.org/citations/15556931 | http://purl.uniprot.org/core/author | "Bonini N.M."xsd:string |
| http://purl.uniprot.org/citations/15556931 | http://purl.uniprot.org/core/author | "Meulener M.C."xsd:string |
| http://purl.uniprot.org/citations/15556931 | http://purl.uniprot.org/core/author | "Auluck P.K."xsd:string |
| http://purl.uniprot.org/citations/15556931 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15556931 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15556931 | http://purl.uniprot.org/core/pages | "2873-2878"xsd:string |
| http://purl.uniprot.org/citations/15556931 | http://purl.uniprot.org/core/title | "Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/15556931 | http://purl.uniprot.org/core/volume | "280"xsd:string |
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