| http://purl.uniprot.org/citations/15557144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15557144 | http://www.w3.org/2000/01/rdf-schema#comment | "The CD154/CD40 interaction is an important pathway of CD4 T cell help for CD8 T cell responses. In this study, we address the role of CD70, a member of the TNF superfamily and the ligand for the T cell costimulatory receptor CD27, in CD40-mediated priming of CD8 T cells. Using an agonistic anti-CD40 mAb to mimic the CD154/CD40 interaction we demonstrate that the priming of OT-I TCR transgenic or endogenous mouse OVA-specific CD8 T cells is critically dependent on CD70/CD27 interaction. CD70 blockade inhibited CD40-mediated clonal expansion of CD8 T cells and reduced the number of memory CD8 T cells generated. Furthermore, CD70 blockade during the initial priming of CD8 T cells inhibited the ability of memory CD8 T cells to expand in response to a second encounter with Ag. Our data indicate that CD70 expression on APCs plays a key role in CD40-dependent CD8 T cell responses."xsd:string |
| http://purl.uniprot.org/citations/15557144 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.173.11.6542"xsd:string |
| http://purl.uniprot.org/citations/15557144 | http://purl.uniprot.org/core/author | "Al-Shamkhani A."xsd:string |
| http://purl.uniprot.org/citations/15557144 | http://purl.uniprot.org/core/author | "Rowley T.F."xsd:string |
| http://purl.uniprot.org/citations/15557144 | http://purl.uniprot.org/core/author | "Taraban V.Y."xsd:string |
| http://purl.uniprot.org/citations/15557144 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15557144 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15557144 | http://purl.uniprot.org/core/pages | "6542-6546"xsd:string |
| http://purl.uniprot.org/citations/15557144 | http://purl.uniprot.org/core/title | "Cutting edge: a critical role for CD70 in CD8 T cell priming by CD40-licensed APCs."xsd:string |
| http://purl.uniprot.org/citations/15557144 | http://purl.uniprot.org/core/volume | "173"xsd:string |
| http://purl.uniprot.org/citations/15557144 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15557144 |
| http://purl.uniprot.org/citations/15557144 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15557144 |
| http://purl.uniprot.org/uniprot/#_O55237-mappedCitation-15557144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15557144 |
| http://purl.uniprot.org/uniprot/#_Q05A52-mappedCitation-15557144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15557144 |
| http://purl.uniprot.org/uniprot/O55237 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15557144 |
| http://purl.uniprot.org/uniprot/Q05A52 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15557144 |