| http://purl.uniprot.org/citations/15557341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15557341 | http://www.w3.org/2000/01/rdf-schema#comment | "SHP-1 is a cytoplasmic SH2 domain containing protein-tyrosine phosphatase (PTP) involved in the negative regulation of multiple signaling pathways in hematopoietic, nervous, and epithelial cells. The thyroid TRK-T3 oncogene consists of the NTRK1 tyrosine kinase domain fused in-frame with sequences of the TFG (TRK-fused gene), encoding a protein of unknown function. TFG contains a coiled-coil domain responsible for TRK-T3 oligomerization. In addition, recent analysis of the sequences outside of the coiled-coil domain suggested possible interactions with other proteins. Based on the presence of a putative SHP-1 SH2-binding site within the TFG sequences, we have investigated the role of the SHP-1 phosphatase in TRK-T3 oncoprotein signaling. In this study we show that SHP-1 interacts with and down-regulates TRK-T3. We provide evidence that SHP-1 SH2 and catalytic domains, respectively, associate with the TFG- and NTRK1-derived portions of TRK-T3. Our data contribute to the definition of cellular mechanisms involved in thyroid tumorigenesis. Moreover, it reveals TFG as a novel protein able to modulate SHP-1 activity."xsd:string |
| http://purl.uniprot.org/citations/15557341 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m407522200"xsd:string |
| http://purl.uniprot.org/citations/15557341 | http://purl.uniprot.org/core/author | "Greco A."xsd:string |
| http://purl.uniprot.org/citations/15557341 | http://purl.uniprot.org/core/author | "Pierotti M.A."xsd:string |
| http://purl.uniprot.org/citations/15557341 | http://purl.uniprot.org/core/author | "Miranda C."xsd:string |
| http://purl.uniprot.org/citations/15557341 | http://purl.uniprot.org/core/author | "Pagliardini S."xsd:string |
| http://purl.uniprot.org/citations/15557341 | http://purl.uniprot.org/core/author | "Raho G."xsd:string |
| http://purl.uniprot.org/citations/15557341 | http://purl.uniprot.org/core/author | "Roccato E."xsd:string |
| http://purl.uniprot.org/citations/15557341 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15557341 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15557341 | http://purl.uniprot.org/core/pages | "3382-3389"xsd:string |
| http://purl.uniprot.org/citations/15557341 | http://purl.uniprot.org/core/title | "Analysis of SHP-1-mediated down-regulation of the TRK-T3 oncoprotein identifies Trk-fused gene (TFG) as a novel SHP-1-interacting protein."xsd:string |
| http://purl.uniprot.org/citations/15557341 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15557341 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15557341 |
| http://purl.uniprot.org/citations/15557341 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15557341 |
| http://purl.uniprot.org/uniprot/#_B4DTD7-mappedCitation-15557341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15557341 |
| http://purl.uniprot.org/uniprot/#_B4DPS0-mappedCitation-15557341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15557341 |
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| http://purl.uniprot.org/uniprot/#_Q92734-mappedCitation-15557341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15557341 |
| http://purl.uniprot.org/uniprot/#_Q7Z426-mappedCitation-15557341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15557341 |
| http://purl.uniprot.org/uniprot/#_Q7Z427-mappedCitation-15557341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15557341 |