| http://purl.uniprot.org/citations/15563469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15563469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15563469 | http://www.w3.org/2000/01/rdf-schema#comment | "Androgens drive sex differentiation, bone and muscle development, and promote growth of hormone-dependent cancers by binding the nuclear androgen receptor (AR), which recruits coactivators to responsive genes. Most nuclear receptors recruit steroid receptor coactivators (SRCs) to their ligand binding domain (LBD) using a leucine-rich motif (LXXLL). AR is believed to recruit unique coactivators to its LBD using an aromatic-rich motif (FXXLF) while recruiting SRCs to its N-terminal domain (NTD) through an alternate mechanism. Here, we report that the AR-LBD interacts with both FXXLF motifs and a subset of LXXLL motifs and that contacts with these LXXLL motifs are both necessary and sufficient for SRC-mediated AR regulation of transcription. Crystal structures of the activated AR in complex with both recruitment motifs reveal that side chains unique to the AR-LBD rearrange to bind either the bulky FXXLF motifs or the more compact LXXLL motifs and that AR utilizes subsidiary contacts with LXXLL flanking sequences to discriminate between LXXLL motifs."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m407046200"xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m407046200"xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Nguyen P."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Nguyen P."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Fletterick R.J."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Fletterick R.J."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Guy R.K."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Guy R.K."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Baxter J.D."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Baxter J.D."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Buehrer B.M."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Buehrer B.M."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Delgado-Rodrigues E."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Delgado-Rodrigues E."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Estebanez-Perpina E."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Estebanez-Perpina E."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Mar E."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Mar E."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Moore J.M.R."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Moore J.M.R."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Webb P."xsd:string |
| http://purl.uniprot.org/citations/15563469 | http://purl.uniprot.org/core/author | "Webb P."xsd:string |