| http://purl.uniprot.org/citations/15572675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15572675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15572675 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms involved in the cytotoxic action of oxysterols in the pathogenesis of atherosclerosis still remain poorly understood. Among the major oxysterols present in oxidized low-density lipoprotein, we show here that 7-ketocholesterol (7-Kchol) induces oxidative stress and/or apoptotic events in human aortic smooth muscle cells (SMCs). This specific effect of 7-Kchol is mediated by a robust upregulation (threefold from the basal level) of Nox-4, a reactive oxygen species (ROS)-generating NAD(P)H oxidase homologue. This effect was highlighted by silencing Nox-4 expression with a specific small interfering RNA, which significantly reduced the 7-Kchol-induced production of ROS and abolished apoptotic events. Furthermore, the 7-Kchol activating pathway included an early triggering of endoplasmic reticulum stress, as assessed by transient intracellular Ca(2+) oscillations, and the induction of the expression of the cell death effector CHOP and of GRP78/Bip chaperone via the activation of IRE-1, all hallmarks of the unfolded protein response (UPR). We also showed that 7-Kchol activated the IRE-1/Jun-NH(2)-terminal kinase (JNK)/AP-1 signaling pathway to promote Nox-4 expression. Silencing of IRE-1 and JNK inhibition downregulated Nox-4 expression and subsequently prevented the UPR-dependent cell death induced by 7-Kchol. These findings demonstrate that Nox-4 plays a key role in 7-Kchol-induced SMC death, which is consistent with the hypothesis that Nox-4/oxysterols are involved in the pathogenesis of atherosclerosis."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.24.10703-10717.2004"xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.24.10703-10717.2004"xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Lizard G."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Lizard G."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Bens M."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Bens M."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Pouzet C."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Pouzet C."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Vandewalle A."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Vandewalle A."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Gougerot-Pocidalo M.-A."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Gougerot-Pocidalo M.-A."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Guichard C."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Guichard C."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Ogier-Denis E."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Ogier-Denis E."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Ollivier V."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Ollivier V."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Elbim C."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Elbim C."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Fay M."xsd:string |
| http://purl.uniprot.org/citations/15572675 | http://purl.uniprot.org/core/author | "Fay M."xsd:string |