| http://purl.uniprot.org/citations/15574331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15574331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15574331 | http://www.w3.org/2000/01/rdf-schema#comment | "CRM1/Exportin1 mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES) by forming a cooperative ternary complex with the NES-bearing substrate and the small GTPase Ran. We present a structural model of human CRM1 based on a combination of X-ray crystallography, homology modeling, and electron microscopy. The architecture of CRM1 resembles that of the import receptor transportin1, with 19 HEAT repeats and a large loop implicated in Ran binding. Residues critical for NES recognition are identified adjacent to the cysteine residue targeted by leptomycin B (LMB), a specific CRM1 inhibitor. We present evidence that a conformational change of the Ran binding loop accounts for the cooperativity of Ran- and substrate binding and for the selective enhancement of CRM1-mediated export by the cofactor RanBP3. Our findings indicate that a single architectural and mechanistic framework can explain the divergent effects of RanGTP on substrate binding by many import and export receptors."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2004.11.018"xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2004.11.018"xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Baudin F."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Baudin F."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Moulin M."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Moulin M."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Mueller C.W."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Mueller C.W."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Petosa C."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Petosa C."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Schoehn G."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Schoehn G."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Bauer U."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Bauer U."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Soler-Lopez M."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Soler-Lopez M."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Mattaj I.W."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Mattaj I.W."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Askjaer P."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Askjaer P."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Steuerwald U."xsd:string |
| http://purl.uniprot.org/citations/15574331 | http://purl.uniprot.org/core/author | "Steuerwald U."xsd:string |