| http://purl.uniprot.org/citations/15578571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15578571 | http://www.w3.org/2000/01/rdf-schema#comment | "Naturally occurring antisense RNA has been detected for a range of eukaryotic genes. Its abundance compared to levels of its complementary sense mRNA appears to be a factor indicating its possible regulatory function. In previous studies, we detected appreciable levels of antisense RNA against the two isoforms (alpha and beta) of the heavy myosin-chain (MyHC) in the myocardium of rats. If this is to play a significant role in gene expression antisense levels should vary in response to external and internal cellular influences. Recently, a bidirectional promoter located in the alpha/beta MyHC intergenic region was described, which was proposed to regulate coordinated transcription of alpha-MyHC sense and beta-MyHC antisense. To study MyHC antisense regulation in neonatal heart, we investigated cultivated myocytes stimulated with either trijodthyronin (T3) as an inductor of alpha-MyHC or phenylephrine with stimulation of beta-MyHC. RNA-quantification of sense and antisense transcripts of both isoforms was performed by real-time RT-PCR. Stimulation by T3 led to an induction of both sense and antisense of alpha-MyHC and to a decrease of beta-MyHC sense and antisense. Phenylephrine increased sense and antisense beta-MyHC but reduced antisense alpha-MyHC. The sense/antisense of alpha- and beta-MyHC ratio was unchanged compared to control. Results indicate a coregulation of sense and antisense MyHC RNA under stimulation of T3 and phenylephrine in neonatal cardiomyocytes."xsd:string |
| http://purl.uniprot.org/citations/15578571 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.20319"xsd:string |
| http://purl.uniprot.org/citations/15578571 | http://purl.uniprot.org/core/author | "Baumann G."xsd:string |
| http://purl.uniprot.org/citations/15578571 | http://purl.uniprot.org/core/author | "Bartsch H."xsd:string |
| http://purl.uniprot.org/citations/15578571 | http://purl.uniprot.org/core/author | "Morano I."xsd:string |
| http://purl.uniprot.org/citations/15578571 | http://purl.uniprot.org/core/author | "Podlowski S."xsd:string |
| http://purl.uniprot.org/citations/15578571 | http://purl.uniprot.org/core/author | "Luther H.P."xsd:string |
| http://purl.uniprot.org/citations/15578571 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15578571 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/15578571 | http://purl.uniprot.org/core/pages | "848-855"xsd:string |
| http://purl.uniprot.org/citations/15578571 | http://purl.uniprot.org/core/title | "Regulation of naturally occurring antisense RNA of myosin heavy chain (MyHC) in neonatal cardiomyocytes."xsd:string |
| http://purl.uniprot.org/citations/15578571 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/15578571 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15578571 |
| http://purl.uniprot.org/citations/15578571 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15578571 |
| http://purl.uniprot.org/uniprot/#_Q63939-mappedCitation-15578571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15578571 |
| http://purl.uniprot.org/uniprot/#_Q9QZV8-mappedCitation-15578571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15578571 |
| http://purl.uniprot.org/uniprot/#_Q0GC39-mappedCitation-15578571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15578571 |
| http://purl.uniprot.org/uniprot/Q63939 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15578571 |
| http://purl.uniprot.org/uniprot/Q0GC39 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15578571 |
| http://purl.uniprot.org/uniprot/Q9QZV8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15578571 |