| http://purl.uniprot.org/citations/15579434 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15579434 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiopoietin-2 (Ang-2) modulates Tie-2 receptor activation. In mouse kidney maturation, Ang-2 is expressed in arteries, with lower levels in tubules, whereas Tie-2 is expressed by endothelia. We hypothesized that Ang-2 deficiency disrupts kidney vessel patterning. The normal renal cortical peritubular space contains fenestrated capillaries, which have few pericytes; they receive water and solutes which proximal tubules reclaim from the glomerular filtrate. In wild-type neonates, alpha smooth muscle actin (alpha SMA), platelet-derived growth factor receptor beta (PDGFR beta), and desmin-expressing cells were not prominent in this compartment. In Ang-2 null mutants, alpha SMA, desmin, and PDGFR beta prominently immunolocalized in cortical peritubular locations. Some alpha SMA-positive cells were closely associated with CD31- and Tie-2-positive peritubular capillary endothelia, and some of the alpha SMA-positive cells expressed PDGFR beta, desmin, and neural/glial cell 2 (NG2), consistent with a pericyte-like identity. Immunoblotting suggested an increase of total and tyrosine-phosphorylated Tie-2 proteins in null mutant versus wild-type kidneys, and electron microscopy confirmed disorganized capillaries and adjacent cells in cortical peritubular spaces in mutant neonate kidneys. Hence, Ang-2 deficiency causes dysmorphogenesis of cortical peritubular capillaries, with adjacent cells expressing pericyte-like markers; we speculate the latter effect is caused by disturbed paracrine signaling between endothelial and surrounding mesenchymal precursor cells."xsd:string |
| http://purl.uniprot.org/citations/15579434 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)63242-7"xsd:string |
| http://purl.uniprot.org/citations/15579434 | http://purl.uniprot.org/core/author | "Woolf A.S."xsd:string |
| http://purl.uniprot.org/citations/15579434 | http://purl.uniprot.org/core/author | "Gale N.W."xsd:string |
| http://purl.uniprot.org/citations/15579434 | http://purl.uniprot.org/core/author | "Yancopoulos G.D."xsd:string |
| http://purl.uniprot.org/citations/15579434 | http://purl.uniprot.org/core/author | "Yuan H.T."xsd:string |
| http://purl.uniprot.org/citations/15579434 | http://purl.uniprot.org/core/author | "Pitera J.E."xsd:string |
| http://purl.uniprot.org/citations/15579434 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15579434 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/15579434 | http://purl.uniprot.org/core/pages | "1895-1906"xsd:string |
| http://purl.uniprot.org/citations/15579434 | http://purl.uniprot.org/core/title | "Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/15579434 | http://purl.uniprot.org/core/volume | "165"xsd:string |
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